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Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
Objective: The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants. Method: A total of 250 preterm infants were divided into neonatal anemic (NA, n = 154) and non-neonatal anemic group (NNA, n...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192839/ https://www.ncbi.nlm.nih.gov/pubmed/34123978 http://dx.doi.org/10.3389/fped.2021.687119 |
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author | Li, Mingyan Lv, Ying Ying, Jionghuan Xu, Lin Chen, Weijun Zheng, Quan Ji, Chai Shao, Jie |
author_facet | Li, Mingyan Lv, Ying Ying, Jionghuan Xu, Lin Chen, Weijun Zheng, Quan Ji, Chai Shao, Jie |
author_sort | Li, Mingyan |
collection | PubMed |
description | Objective: The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants. Method: A total of 250 preterm infants were divided into neonatal anemic (NA, n = 154) and non-neonatal anemic group (NNA, n = 96). Iron supplements at a dose of 2 mg/kg per day were given from 40 weeks' gestational age to 6 months. Iron status parameters were measured at 3 and 6 months, respectively. Prevalence of iron deficiency (ID) and iron deficiency anemia (IDA), and the correlated factors were analyzed. Growth and side-effects were monitored. Results: There were no significant differences for the prevalence of ID or IDA between the two groups. Multivariate regression analyses showed that higher Hb at birth and early treatment of blood transfusion reduced the risk of ID/IDA at 3 months (all p < 0.05); while higher level of Hb at 3 months (p = 0.004) and formula feeding reduced the occurrence of ID/IDA at 6 months (p < 0.05); males had a 3.35 times higher risk to develop ID/IDA than girls (p = 0.021). No differences in growth and side effects were found. Conclusion: A daily dose of 2 mg/kg iron supplement is beneficial to maintain iron homeostasis in majority preterm infants within 6 months regardless of their neonatal anemia history. Under the routine iron supplementation, Hb level at birth and at 3 months, early treatment of blood transfusion, gender and feeding patterns are the major factors affecting the prevalence of ID/IDA among preterm infants in infancy. |
format | Online Article Text |
id | pubmed-8192839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81928392021-06-12 Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants Li, Mingyan Lv, Ying Ying, Jionghuan Xu, Lin Chen, Weijun Zheng, Quan Ji, Chai Shao, Jie Front Pediatr Pediatrics Objective: The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants. Method: A total of 250 preterm infants were divided into neonatal anemic (NA, n = 154) and non-neonatal anemic group (NNA, n = 96). Iron supplements at a dose of 2 mg/kg per day were given from 40 weeks' gestational age to 6 months. Iron status parameters were measured at 3 and 6 months, respectively. Prevalence of iron deficiency (ID) and iron deficiency anemia (IDA), and the correlated factors were analyzed. Growth and side-effects were monitored. Results: There were no significant differences for the prevalence of ID or IDA between the two groups. Multivariate regression analyses showed that higher Hb at birth and early treatment of blood transfusion reduced the risk of ID/IDA at 3 months (all p < 0.05); while higher level of Hb at 3 months (p = 0.004) and formula feeding reduced the occurrence of ID/IDA at 6 months (p < 0.05); males had a 3.35 times higher risk to develop ID/IDA than girls (p = 0.021). No differences in growth and side effects were found. Conclusion: A daily dose of 2 mg/kg iron supplement is beneficial to maintain iron homeostasis in majority preterm infants within 6 months regardless of their neonatal anemia history. Under the routine iron supplementation, Hb level at birth and at 3 months, early treatment of blood transfusion, gender and feeding patterns are the major factors affecting the prevalence of ID/IDA among preterm infants in infancy. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8192839/ /pubmed/34123978 http://dx.doi.org/10.3389/fped.2021.687119 Text en Copyright © 2021 Li, Lv, Ying, Xu, Chen, Zheng, Ji and Shao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Li, Mingyan Lv, Ying Ying, Jionghuan Xu, Lin Chen, Weijun Zheng, Quan Ji, Chai Shao, Jie Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants |
title | Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants |
title_full | Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants |
title_fullStr | Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants |
title_full_unstemmed | Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants |
title_short | Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants |
title_sort | effect of daily iron supplementation on infantile iron homeostasis in preterm infants |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192839/ https://www.ncbi.nlm.nih.gov/pubmed/34123978 http://dx.doi.org/10.3389/fped.2021.687119 |
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