Cargando…

Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants

Objective: The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants. Method: A total of 250 preterm infants were divided into neonatal anemic (NA, n = 154) and non-neonatal anemic group (NNA, n...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Mingyan, Lv, Ying, Ying, Jionghuan, Xu, Lin, Chen, Weijun, Zheng, Quan, Ji, Chai, Shao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192839/
https://www.ncbi.nlm.nih.gov/pubmed/34123978
http://dx.doi.org/10.3389/fped.2021.687119
_version_ 1783706121961209856
author Li, Mingyan
Lv, Ying
Ying, Jionghuan
Xu, Lin
Chen, Weijun
Zheng, Quan
Ji, Chai
Shao, Jie
author_facet Li, Mingyan
Lv, Ying
Ying, Jionghuan
Xu, Lin
Chen, Weijun
Zheng, Quan
Ji, Chai
Shao, Jie
author_sort Li, Mingyan
collection PubMed
description Objective: The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants. Method: A total of 250 preterm infants were divided into neonatal anemic (NA, n = 154) and non-neonatal anemic group (NNA, n = 96). Iron supplements at a dose of 2 mg/kg per day were given from 40 weeks' gestational age to 6 months. Iron status parameters were measured at 3 and 6 months, respectively. Prevalence of iron deficiency (ID) and iron deficiency anemia (IDA), and the correlated factors were analyzed. Growth and side-effects were monitored. Results: There were no significant differences for the prevalence of ID or IDA between the two groups. Multivariate regression analyses showed that higher Hb at birth and early treatment of blood transfusion reduced the risk of ID/IDA at 3 months (all p < 0.05); while higher level of Hb at 3 months (p = 0.004) and formula feeding reduced the occurrence of ID/IDA at 6 months (p < 0.05); males had a 3.35 times higher risk to develop ID/IDA than girls (p = 0.021). No differences in growth and side effects were found. Conclusion: A daily dose of 2 mg/kg iron supplement is beneficial to maintain iron homeostasis in majority preterm infants within 6 months regardless of their neonatal anemia history. Under the routine iron supplementation, Hb level at birth and at 3 months, early treatment of blood transfusion, gender and feeding patterns are the major factors affecting the prevalence of ID/IDA among preterm infants in infancy.
format Online
Article
Text
id pubmed-8192839
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81928392021-06-12 Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants Li, Mingyan Lv, Ying Ying, Jionghuan Xu, Lin Chen, Weijun Zheng, Quan Ji, Chai Shao, Jie Front Pediatr Pediatrics Objective: The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants. Method: A total of 250 preterm infants were divided into neonatal anemic (NA, n = 154) and non-neonatal anemic group (NNA, n = 96). Iron supplements at a dose of 2 mg/kg per day were given from 40 weeks' gestational age to 6 months. Iron status parameters were measured at 3 and 6 months, respectively. Prevalence of iron deficiency (ID) and iron deficiency anemia (IDA), and the correlated factors were analyzed. Growth and side-effects were monitored. Results: There were no significant differences for the prevalence of ID or IDA between the two groups. Multivariate regression analyses showed that higher Hb at birth and early treatment of blood transfusion reduced the risk of ID/IDA at 3 months (all p < 0.05); while higher level of Hb at 3 months (p = 0.004) and formula feeding reduced the occurrence of ID/IDA at 6 months (p < 0.05); males had a 3.35 times higher risk to develop ID/IDA than girls (p = 0.021). No differences in growth and side effects were found. Conclusion: A daily dose of 2 mg/kg iron supplement is beneficial to maintain iron homeostasis in majority preterm infants within 6 months regardless of their neonatal anemia history. Under the routine iron supplementation, Hb level at birth and at 3 months, early treatment of blood transfusion, gender and feeding patterns are the major factors affecting the prevalence of ID/IDA among preterm infants in infancy. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8192839/ /pubmed/34123978 http://dx.doi.org/10.3389/fped.2021.687119 Text en Copyright © 2021 Li, Lv, Ying, Xu, Chen, Zheng, Ji and Shao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Li, Mingyan
Lv, Ying
Ying, Jionghuan
Xu, Lin
Chen, Weijun
Zheng, Quan
Ji, Chai
Shao, Jie
Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
title Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
title_full Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
title_fullStr Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
title_full_unstemmed Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
title_short Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants
title_sort effect of daily iron supplementation on infantile iron homeostasis in preterm infants
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192839/
https://www.ncbi.nlm.nih.gov/pubmed/34123978
http://dx.doi.org/10.3389/fped.2021.687119
work_keys_str_mv AT limingyan effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants
AT lvying effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants
AT yingjionghuan effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants
AT xulin effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants
AT chenweijun effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants
AT zhengquan effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants
AT jichai effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants
AT shaojie effectofdailyironsupplementationoninfantileironhomeostasisinpreterminfants