A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.

The inv(7)(p15q34) chromosomal abnormality which juxtaposes part of the HOXA gene cluster on 7p15 to the TCRβ locus on 7q34, has been described in a subset of cases of T-cell lymphoblastic leukemia, but its presence in cases of B-cell lymphoblastic leukemia is virtually unknown. Herewith, we report...

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Detalles Bibliográficos
Autores principales: Andrew, Bernhisel, Attilio, Orazi, Sumit, Guar, Vijay, Tonk, Reshad, Ghafouri Sayed, Osvaldo, Padilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192865/
https://www.ncbi.nlm.nih.gov/pubmed/34150490
http://dx.doi.org/10.1016/j.lrr.2021.100250
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author Andrew, Bernhisel
Attilio, Orazi
Sumit, Guar
Vijay, Tonk
Reshad, Ghafouri Sayed
Osvaldo, Padilla
author_facet Andrew, Bernhisel
Attilio, Orazi
Sumit, Guar
Vijay, Tonk
Reshad, Ghafouri Sayed
Osvaldo, Padilla
author_sort Andrew, Bernhisel
collection PubMed
description The inv(7)(p15q34) chromosomal abnormality which juxtaposes part of the HOXA gene cluster on 7p15 to the TCRβ locus on 7q34, has been described in a subset of cases of T-cell lymphoblastic leukemia, but its presence in cases of B-cell lymphoblastic leukemia is virtually unknown. Herewith, we report a case of a B-cell lymphoblastic leukemia with inv(7)(p15q34). The patient received standard induction chemotherapy, which failed to produce remission. After treatment with blinatumomab, a bispecific T-cell engager, the follow-up bone marrow biopsy showed no evidence of persistent/ relapsed B-cell lymphoblastic leukemia. The unique cytogenetics of this case may have contributed to its resistance of standard induction chemotherapy.
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spelling pubmed-81928652021-06-17 A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature. Andrew, Bernhisel Attilio, Orazi Sumit, Guar Vijay, Tonk Reshad, Ghafouri Sayed Osvaldo, Padilla Leuk Res Rep Article The inv(7)(p15q34) chromosomal abnormality which juxtaposes part of the HOXA gene cluster on 7p15 to the TCRβ locus on 7q34, has been described in a subset of cases of T-cell lymphoblastic leukemia, but its presence in cases of B-cell lymphoblastic leukemia is virtually unknown. Herewith, we report a case of a B-cell lymphoblastic leukemia with inv(7)(p15q34). The patient received standard induction chemotherapy, which failed to produce remission. After treatment with blinatumomab, a bispecific T-cell engager, the follow-up bone marrow biopsy showed no evidence of persistent/ relapsed B-cell lymphoblastic leukemia. The unique cytogenetics of this case may have contributed to its resistance of standard induction chemotherapy. Elsevier 2021-06-01 /pmc/articles/PMC8192865/ /pubmed/34150490 http://dx.doi.org/10.1016/j.lrr.2021.100250 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Andrew, Bernhisel
Attilio, Orazi
Sumit, Guar
Vijay, Tonk
Reshad, Ghafouri Sayed
Osvaldo, Padilla
A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.
title A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.
title_full A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.
title_fullStr A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.
title_full_unstemmed A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.
title_short A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.
title_sort rare case of b cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192865/
https://www.ncbi.nlm.nih.gov/pubmed/34150490
http://dx.doi.org/10.1016/j.lrr.2021.100250
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