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Hepatocyte proteomes reveal the role of protein disulfide isomerase 4 in alpha 1-antitrypsin deficiency

BACKGROUND & AIMS: A single point mutation in the Z-variant of alpha 1-antitrypsin (Z-AAT) alone can lead to both a protein folding and trafficking defect, preventing its exit from the endoplasmic reticulum (ER), and the formation of aggregates that are retained as inclusions within the ER of he...

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Detalles Bibliográficos
Autores principales:	Karatas, Esra, Raymond, Anne-Aurélie, Leon, Céline, Dupuy, Jean-William, Di-Tommaso, Sylvaine, Senant, Nathalie, Collardeau-Frachon, Sophie, Ruiz, Mathias, Lachaux, Alain, Saltel, Frédéric, Bouchecareilh, Marion
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192868/ https://www.ncbi.nlm.nih.gov/pubmed/34151245 http://dx.doi.org/10.1016/j.jhepr.2021.100297

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