Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K(+) channel K(v)7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are associated with diabetes, and LQTS patients have a hig...

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Detalles Bibliográficos
Autores principales: Lubberding, Anniek F., Zhang, Jinyi, Lundh, Morten, Nielsen, Thomas Svava, Søndergaard, Mathilde S., Villadsen, Maria, Skovhøj, Emil Z., Boer, Geke A., Hansen, Jakob B., Thomsen, Morten B., Treebak, Jonas T., Holst, Jens J., Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice, Torekov, Signe S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192901/
https://www.ncbi.nlm.nih.gov/pubmed/34112814
http://dx.doi.org/10.1038/s41598-021-90452-8

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