BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

R-loop structures act as modulators of physiological processes such as transcription termination, gene regulation, and DNA repair. However, they can cause transcription-replication conflicts and give rise to genomic instability, particularly at telomeres, which are prone to forming DNA secondary str...

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Detalles Bibliográficos
Autores principales: Vohhodina, Jekaterina, Goehring, Liana J., Liu, Ben, Kong, Qing, Botchkarev Jr., Vladimir V., Huynh, Mai, Liu, Zhiqi, Abderazzaq, Fieda O., Clark, Allison P., Ficarro, Scott B., Marto, Jarrod A., Hatchi, Elodie, Livingston, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192922/
https://www.ncbi.nlm.nih.gov/pubmed/34112789
http://dx.doi.org/10.1038/s41467-021-23716-6

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