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Transfer RNA-derived fragments in aging Caenorhabditis elegans originate from abundant homologous gene copies

Small RNAs that originate from transfer RNA (tRNA) species, tRNA-derived fragments (tRFs), play diverse biological functions but little is known for their association with aging. Moreover, biochemical aspects of tRNAs limit discovery of functional tRFs by high throughput sequencing. In particular, g...

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Detalles Bibliográficos
Autores principales: Shin, GiWon, Koo, Hee Jung, Seo, Mihwa, Lee, Seung-Jae V., Nam, Hong Gil, Jung, Gyoo Yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192933/
https://www.ncbi.nlm.nih.gov/pubmed/34112855
http://dx.doi.org/10.1038/s41598-021-91724-z