Cargando…

Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration

The purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patients who un...

Descripción completa

Detalles Bibliográficos
Autores principales: Maruyama-Inoue, Maiko, Inoue, Tatsuya, Mohamed, Shaheeda, Kitajima, Yoko, Ikeda, Shoko, Ito, Arisa, Kadonosono, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192945/
https://www.ncbi.nlm.nih.gov/pubmed/34112856
http://dx.doi.org/10.1038/s41598-021-91832-w
_version_ 1783706146538782720
author Maruyama-Inoue, Maiko
Inoue, Tatsuya
Mohamed, Shaheeda
Kitajima, Yoko
Ikeda, Shoko
Ito, Arisa
Kadonosono, Kazuaki
author_facet Maruyama-Inoue, Maiko
Inoue, Tatsuya
Mohamed, Shaheeda
Kitajima, Yoko
Ikeda, Shoko
Ito, Arisa
Kadonosono, Kazuaki
author_sort Maruyama-Inoue, Maiko
collection PubMed
description The purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patients who underwent ≥ 10 intravitreal anti-VEGF injections between April 2009 and December 2019 was conducted. Elevated IOP was defined as IOP ≥ 25 mmHg at one visit. Cases with elevated IOP resulting from IVI were identified. Furthermore, the association between elevated IOP and some parameters, as the risk factors that influence elevated IOP, was investigated. A total of 402 eyes of 370 patients were included in this study. Twenty-eight eyes of 26 patients (7.0%) were identified as cases with elevated IOP after IVI. The mean time of elevation after baseline was 50.6 ± 26.5 months. History of glaucoma (p = 0.021; odds ratio, 5.85), treatment modality (p = 0.019; odds ratio, 6.32), and total number of injections (p = 0.003; odds ratio, 1.03) were significantly associated with elevated IOP. A late complication of elevated IOP is associated with IVI in patients with AMD. Particularly, history of glaucoma and treat and extend regimen with frequent injections were found to be risk factors of elevated IOP.
format Online
Article
Text
id pubmed-8192945
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-81929452021-06-14 Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration Maruyama-Inoue, Maiko Inoue, Tatsuya Mohamed, Shaheeda Kitajima, Yoko Ikeda, Shoko Ito, Arisa Kadonosono, Kazuaki Sci Rep Article The purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patients who underwent ≥ 10 intravitreal anti-VEGF injections between April 2009 and December 2019 was conducted. Elevated IOP was defined as IOP ≥ 25 mmHg at one visit. Cases with elevated IOP resulting from IVI were identified. Furthermore, the association between elevated IOP and some parameters, as the risk factors that influence elevated IOP, was investigated. A total of 402 eyes of 370 patients were included in this study. Twenty-eight eyes of 26 patients (7.0%) were identified as cases with elevated IOP after IVI. The mean time of elevation after baseline was 50.6 ± 26.5 months. History of glaucoma (p = 0.021; odds ratio, 5.85), treatment modality (p = 0.019; odds ratio, 6.32), and total number of injections (p = 0.003; odds ratio, 1.03) were significantly associated with elevated IOP. A late complication of elevated IOP is associated with IVI in patients with AMD. Particularly, history of glaucoma and treat and extend regimen with frequent injections were found to be risk factors of elevated IOP. Nature Publishing Group UK 2021-06-10 /pmc/articles/PMC8192945/ /pubmed/34112856 http://dx.doi.org/10.1038/s41598-021-91832-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Maruyama-Inoue, Maiko
Inoue, Tatsuya
Mohamed, Shaheeda
Kitajima, Yoko
Ikeda, Shoko
Ito, Arisa
Kadonosono, Kazuaki
Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_full Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_fullStr Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_full_unstemmed Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_short Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_sort incidence of elevated intraocular pressure after intravitreal injection in japanese patients with age-related macular degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192945/
https://www.ncbi.nlm.nih.gov/pubmed/34112856
http://dx.doi.org/10.1038/s41598-021-91832-w
work_keys_str_mv AT maruyamainouemaiko incidenceofelevatedintraocularpressureafterintravitrealinjectioninjapanesepatientswithagerelatedmaculardegeneration
AT inouetatsuya incidenceofelevatedintraocularpressureafterintravitrealinjectioninjapanesepatientswithagerelatedmaculardegeneration
AT mohamedshaheeda incidenceofelevatedintraocularpressureafterintravitrealinjectioninjapanesepatientswithagerelatedmaculardegeneration
AT kitajimayoko incidenceofelevatedintraocularpressureafterintravitrealinjectioninjapanesepatientswithagerelatedmaculardegeneration
AT ikedashoko incidenceofelevatedintraocularpressureafterintravitrealinjectioninjapanesepatientswithagerelatedmaculardegeneration
AT itoarisa incidenceofelevatedintraocularpressureafterintravitrealinjectioninjapanesepatientswithagerelatedmaculardegeneration
AT kadonosonokazuaki incidenceofelevatedintraocularpressureafterintravitrealinjectioninjapanesepatientswithagerelatedmaculardegeneration