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The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach

The Müller-Lyer Illusion (MLI) has been suggested as a potential marker for the perceptual impairments observed in schizophrenia patients. Along with some positive symptoms, these deficits are not easily modeled in rodent experiments, and novel animal models are warranted. Previously, MK-801 was sho...

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Autores principales: Costa, Ana Luísa Lamounier, Silva, Ronaldo Coelho, Coelho-Cordeiro, Pedro H., da Silveira, Fernando Silva, Barros, Marilia, Caixeta, Fabio Viegas, Maior, Rafael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192968/
https://www.ncbi.nlm.nih.gov/pubmed/34122024
http://dx.doi.org/10.3389/fnbeh.2021.641776
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author Costa, Ana Luísa Lamounier
Silva, Ronaldo Coelho
Coelho-Cordeiro, Pedro H.
da Silveira, Fernando Silva
Barros, Marilia
Caixeta, Fabio Viegas
Maior, Rafael S.
author_facet Costa, Ana Luísa Lamounier
Silva, Ronaldo Coelho
Coelho-Cordeiro, Pedro H.
da Silveira, Fernando Silva
Barros, Marilia
Caixeta, Fabio Viegas
Maior, Rafael S.
author_sort Costa, Ana Luísa Lamounier
collection PubMed
description The Müller-Lyer Illusion (MLI) has been suggested as a potential marker for the perceptual impairments observed in schizophrenia patients. Along with some positive symptoms, these deficits are not easily modeled in rodent experiments, and novel animal models are warranted. Previously, MK-801 was shown to reduce susceptibility to MLI in monkeys, raising the prospects of an effective perception-based model. Here, we evaluate the translational feasibility of the MLI task under NMDA receptor blockage as a primate model for schizophrenia. In Experiment 1, eight capuchin monkeys (Sapajus spp.) were trained on a touchscreen MLI task. Upon reaching the learning criteria, the monkeys were given ketamine (0.3 mg/kg; i.m.) or saline on four consecutive days and then retested on the MLI task. In Experiment 2, eight chronic schizophrenia patients (and eight matching controls) were tested on the Brentano version of the MLI. Under saline treatment, monkeys were susceptible to MLI, similarly to healthy human participants. Repeated ketamine administrations, however, failed to improve their performance as previous results with MK-801 had shown. Schizophrenic patients, on the other hand, showed a higher susceptibility to MLI when compared to healthy controls. In light of the present and previous studies, the MLI task shows consistent results across monkeys and humans. In spite of potentially being an interesting translational model of schizophrenia, the MLI task warrants further refinement in non-human primates and a broader sample of schizophrenia subtypes.
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spelling pubmed-81929682021-06-12 The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach Costa, Ana Luísa Lamounier Silva, Ronaldo Coelho Coelho-Cordeiro, Pedro H. da Silveira, Fernando Silva Barros, Marilia Caixeta, Fabio Viegas Maior, Rafael S. Front Behav Neurosci Behavioral Neuroscience The Müller-Lyer Illusion (MLI) has been suggested as a potential marker for the perceptual impairments observed in schizophrenia patients. Along with some positive symptoms, these deficits are not easily modeled in rodent experiments, and novel animal models are warranted. Previously, MK-801 was shown to reduce susceptibility to MLI in monkeys, raising the prospects of an effective perception-based model. Here, we evaluate the translational feasibility of the MLI task under NMDA receptor blockage as a primate model for schizophrenia. In Experiment 1, eight capuchin monkeys (Sapajus spp.) were trained on a touchscreen MLI task. Upon reaching the learning criteria, the monkeys were given ketamine (0.3 mg/kg; i.m.) or saline on four consecutive days and then retested on the MLI task. In Experiment 2, eight chronic schizophrenia patients (and eight matching controls) were tested on the Brentano version of the MLI. Under saline treatment, monkeys were susceptible to MLI, similarly to healthy human participants. Repeated ketamine administrations, however, failed to improve their performance as previous results with MK-801 had shown. Schizophrenic patients, on the other hand, showed a higher susceptibility to MLI when compared to healthy controls. In light of the present and previous studies, the MLI task shows consistent results across monkeys and humans. In spite of potentially being an interesting translational model of schizophrenia, the MLI task warrants further refinement in non-human primates and a broader sample of schizophrenia subtypes. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8192968/ /pubmed/34122024 http://dx.doi.org/10.3389/fnbeh.2021.641776 Text en Copyright © 2021 Costa, Silva, Coelho-Cordeiro, da Silveira, Barros, Caixeta and Maior. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Costa, Ana Luísa Lamounier
Silva, Ronaldo Coelho
Coelho-Cordeiro, Pedro H.
da Silveira, Fernando Silva
Barros, Marilia
Caixeta, Fabio Viegas
Maior, Rafael S.
The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach
title The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach
title_full The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach
title_fullStr The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach
title_full_unstemmed The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach
title_short The Perception of the Müller-Lyer Visual Illusion in Schizophrenics and Non-human Primates: A Translational Approach
title_sort perception of the müller-lyer visual illusion in schizophrenics and non-human primates: a translational approach
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192968/
https://www.ncbi.nlm.nih.gov/pubmed/34122024
http://dx.doi.org/10.3389/fnbeh.2021.641776
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