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Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination
INTRODUCTION: Pluripotent stem cells (PSCs) are promising tools for modern regenerative medicine applications because of their stemness properties, which include unlimited self-renewal and the ability to differentiate into all cell types in the body. Evidence suggests that a rare population of cells...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193020/ https://www.ncbi.nlm.nih.gov/pubmed/34115316 http://dx.doi.org/10.1007/s12015-021-10199-7 |
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author | Barati, Mojgan Akhondi, Maryam Mousavi, Narges Sabahi Haghparast, Newsha Ghodsi, Asma Baharvand, Hossein Ebrahimi, Marzieh Hassani, Seyedeh-Nafiseh |
author_facet | Barati, Mojgan Akhondi, Maryam Mousavi, Narges Sabahi Haghparast, Newsha Ghodsi, Asma Baharvand, Hossein Ebrahimi, Marzieh Hassani, Seyedeh-Nafiseh |
author_sort | Barati, Mojgan |
collection | PubMed |
description | INTRODUCTION: Pluripotent stem cells (PSCs) are promising tools for modern regenerative medicine applications because of their stemness properties, which include unlimited self-renewal and the ability to differentiate into all cell types in the body. Evidence suggests that a rare population of cells within a tumor, termed cancer stem cells (CSCs), exhibit stemness and phenotypic plasticity properties that are primarily responsible for resistance to chemotherapy, radiotherapy, metastasis, cancer development, and tumor relapse. Different therapeutic approaches that target CSCs have been developed for tumor eradication. RESULTS AND DISCUSSION: In this review, we first provide an overview of different viewpoints about the origin of CSCs. Particular attention has been paid to views believe that CSCs are probably appeared through dysregulation of very small embryonic-like stem cells (VSELs) which reside in various tissues as the main candidate for tissue-specific stem cells. The expression of pluripotency markers in these two types of cells can strengthen the validity of this theory. In this regard, we discuss the common properties of CSCs and PSCs, and highlight the potential of PSCs in cancer studies, therapeutic applications, as well as educating the immune system against CSCs. CONCLUSION: In conclusion, the resemblance of CSCs to PSCs can provide an appropriate source of CSC-specific antigens through cultivation of PSCs which brings to light promising ideas for prophylactic and therapeutic cancer vaccine development. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-8193020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-81930202021-06-11 Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination Barati, Mojgan Akhondi, Maryam Mousavi, Narges Sabahi Haghparast, Newsha Ghodsi, Asma Baharvand, Hossein Ebrahimi, Marzieh Hassani, Seyedeh-Nafiseh Stem Cell Rev Rep Article INTRODUCTION: Pluripotent stem cells (PSCs) are promising tools for modern regenerative medicine applications because of their stemness properties, which include unlimited self-renewal and the ability to differentiate into all cell types in the body. Evidence suggests that a rare population of cells within a tumor, termed cancer stem cells (CSCs), exhibit stemness and phenotypic plasticity properties that are primarily responsible for resistance to chemotherapy, radiotherapy, metastasis, cancer development, and tumor relapse. Different therapeutic approaches that target CSCs have been developed for tumor eradication. RESULTS AND DISCUSSION: In this review, we first provide an overview of different viewpoints about the origin of CSCs. Particular attention has been paid to views believe that CSCs are probably appeared through dysregulation of very small embryonic-like stem cells (VSELs) which reside in various tissues as the main candidate for tissue-specific stem cells. The expression of pluripotency markers in these two types of cells can strengthen the validity of this theory. In this regard, we discuss the common properties of CSCs and PSCs, and highlight the potential of PSCs in cancer studies, therapeutic applications, as well as educating the immune system against CSCs. CONCLUSION: In conclusion, the resemblance of CSCs to PSCs can provide an appropriate source of CSC-specific antigens through cultivation of PSCs which brings to light promising ideas for prophylactic and therapeutic cancer vaccine development. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2021-06-11 2021 /pmc/articles/PMC8193020/ /pubmed/34115316 http://dx.doi.org/10.1007/s12015-021-10199-7 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Barati, Mojgan Akhondi, Maryam Mousavi, Narges Sabahi Haghparast, Newsha Ghodsi, Asma Baharvand, Hossein Ebrahimi, Marzieh Hassani, Seyedeh-Nafiseh Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination |
title | Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination |
title_full | Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination |
title_fullStr | Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination |
title_full_unstemmed | Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination |
title_short | Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination |
title_sort | pluripotent stem cells: cancer study, therapy, and vaccination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193020/ https://www.ncbi.nlm.nih.gov/pubmed/34115316 http://dx.doi.org/10.1007/s12015-021-10199-7 |
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