Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson’s Disease

BACKGROUND: Aggregation and neurotoxicity of the presynaptic protein α-synuclein and the progressive loss of nigral dopaminergic neurons are believed to be the key hallmarks of Parkinson’s disease (PD). A53T mutant α-synuclein causes early onset PD and more severe manifestations. A growing body of e...

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Detalles Bibliográficos
Autores principales: Li, Huiying, Wang, Hongquan, Zhang, Ling, Wang, Manshi, Li, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193045/
https://www.ncbi.nlm.nih.gov/pubmed/34121985
http://dx.doi.org/10.3389/fnins.2021.647266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193045/
https://www.ncbi.nlm.nih.gov/pubmed/34121985
http://dx.doi.org/10.3389/fnins.2021.647266

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