Factors associated with clinical outcomes of pediatric dengue shock syndrome admitted to pediatric intensive care unit: A retrospective cohort study

BACKGROUND: Dengue shock syndrome (DSS) in children is a challenging infectious disease due to its high mortality rate. Several factors can contribute to the DSS patients’ outcomes. Here we defined factors associated with clinical outcomes of patients with DSS in Pediatric Intensive Care Unit (PICU). METHODS: We retrospectively collected data from January 2016 to May 2020 of patients who had been diagnosed with DSS and admitted to PICU in our tertiary referral hospital. Bivariate analysis and logistic regression were used to evaluate independent predictors of the study outcomes. RESULTS: Overall, 146 patients were enrolled in this study, including 53.4% males and 46.6% females. The mortality rate during the study period was 5.5%. Fluid overload percentage, shock condition at PICU admission, DIC, and AKI were independent predictors for DSS mortality in logistic regression test with p < 0.05. There were several factors correlated with prolonged stay, including disseminated intravascular coagulation (DIC) (RR 15.26; 95% CI: 4.97–46.81), and nutritional status (RR 16.47; 95% CI: 3.72–72.9). CONCLUSION: Fluid overload percentage, shock condition at PICU admission, DIC, and AKI are independent predictors for DSS mortality. Several factors contribute to prolonged PICU stay, including DIC and nutritional status.