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Co-evolution of strain design methods based on flux balance and elementary mode analysis
More than a decade ago, the first genome-scale metabolic models for two of the most relevant microbes for biotechnology applications, Escherichia coli and Saccaromyces cerevisiae, were published. Shortly after followed the publication of OptKnock, the first strain design method using bilevel optimiz...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193246/ https://www.ncbi.nlm.nih.gov/pubmed/34150512 http://dx.doi.org/10.1016/j.meteno.2015.04.001 |