Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

Despite the remarkable success of chimeric antigen receptor (CAR)-T cells against hematologic malignancies, severe off-tumor effects have constrained their use against solid tumors. Recently, CAR-engineered natural killer (NK) cells have emerged as an effective and safe alternative. Here, we demonst...

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Detalles Bibliográficos
Autores principales: Portillo, Ana L., Hogg, Richard, Poznanski, Sophie M., Rojas, Eduardo A., Cashell, Niamh J., Hammill, Joanne A., Chew, Marianne V., Shenouda, Mira M., Ritchie, Tyrah M., Cao, Quynh T., Hirota, Jeremy A., Dhesy-Thind, Sukhbinder, Bramson, Jonathan L., Ashkar, Ali A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193615/
https://www.ncbi.nlm.nih.gov/pubmed/34159300
http://dx.doi.org/10.1016/j.isci.2021.102619

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