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Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city

Hong Kong is an intermediate tuberculosis (TB) burden city in Asia Pacific with slow decline of case notification in the last decade. By 24-loci mycobacterial interspersed repetitive units – variable number of tandem repeats genotyping, we examined 534 Mycobacterium tuberculosis isolates collected f...

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Autores principales: Lee, Shui Shan, Chan, Denise Pui Chung, Wong, Ngai Sze, Lui, Grace Chung Yan, To, Kin Wang, Kam, Joseph Kai Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193765/
https://www.ncbi.nlm.nih.gov/pubmed/34006336
http://dx.doi.org/10.1017/S0950268821001199
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author Lee, Shui Shan
Chan, Denise Pui Chung
Wong, Ngai Sze
Lui, Grace Chung Yan
To, Kin Wang
Kam, Joseph Kai Man
author_facet Lee, Shui Shan
Chan, Denise Pui Chung
Wong, Ngai Sze
Lui, Grace Chung Yan
To, Kin Wang
Kam, Joseph Kai Man
author_sort Lee, Shui Shan
collection PubMed
description Hong Kong is an intermediate tuberculosis (TB) burden city in Asia Pacific with slow decline of case notification in the last decade. By 24-loci mycobacterial interspersed repetitive units – variable number of tandem repeats genotyping, we examined 534 Mycobacterium tuberculosis isolates collected from culture-positive hospitalised TB patients in a 1.7 million population geographic region in the city. Overall, 286 (75%) were classified as Beijing genotype, of which 216 (76%) and 59 (21%) belonged to modern and ancient sub-lineage, respectively. Only two cases were genetically clustered while spatial clustering was absent. Male gender, permanent residency in Hong Kong and born in Hong Kong or Mainland China were associated with Beijing genotype. The high prevalence of Beijing modern lineage was similar to that in East Asia, which reflected the pattern resulting from population migration. The paucity of clustering suggested that reactivation accounted for most of the TB disease cases, which was and echoed by observation that half were 60 years old or above, and the presence of co-morbid medical conditions. The predominance of reactivation TB cases in intermediate burden localities implies that the detection and control of latent TB infection would be the major challenge in achieving TB elimination.
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spelling pubmed-81937652021-06-24 Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city Lee, Shui Shan Chan, Denise Pui Chung Wong, Ngai Sze Lui, Grace Chung Yan To, Kin Wang Kam, Joseph Kai Man Epidemiol Infect Short Paper Hong Kong is an intermediate tuberculosis (TB) burden city in Asia Pacific with slow decline of case notification in the last decade. By 24-loci mycobacterial interspersed repetitive units – variable number of tandem repeats genotyping, we examined 534 Mycobacterium tuberculosis isolates collected from culture-positive hospitalised TB patients in a 1.7 million population geographic region in the city. Overall, 286 (75%) were classified as Beijing genotype, of which 216 (76%) and 59 (21%) belonged to modern and ancient sub-lineage, respectively. Only two cases were genetically clustered while spatial clustering was absent. Male gender, permanent residency in Hong Kong and born in Hong Kong or Mainland China were associated with Beijing genotype. The high prevalence of Beijing modern lineage was similar to that in East Asia, which reflected the pattern resulting from population migration. The paucity of clustering suggested that reactivation accounted for most of the TB disease cases, which was and echoed by observation that half were 60 years old or above, and the presence of co-morbid medical conditions. The predominance of reactivation TB cases in intermediate burden localities implies that the detection and control of latent TB infection would be the major challenge in achieving TB elimination. Cambridge University Press 2021-05-19 /pmc/articles/PMC8193765/ /pubmed/34006336 http://dx.doi.org/10.1017/S0950268821001199 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Paper
Lee, Shui Shan
Chan, Denise Pui Chung
Wong, Ngai Sze
Lui, Grace Chung Yan
To, Kin Wang
Kam, Joseph Kai Man
Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city
title Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city
title_full Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city
title_fullStr Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city
title_full_unstemmed Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city
title_short Distribution of molecular strains of Mycobacterium tuberculosis in an intermediate burden Asia Pacific city
title_sort distribution of molecular strains of mycobacterium tuberculosis in an intermediate burden asia pacific city
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193765/
https://www.ncbi.nlm.nih.gov/pubmed/34006336
http://dx.doi.org/10.1017/S0950268821001199
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