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Targeted Drug Delivery Systems for Kidney Diseases

Kidney diseases have gradually become a global health burden. Along with the development of nanotechnology, many hybrids or nanomaterials have been utilized to promote treatment efficiency with negligible side effects. These therapeutic agents have been successfully applied in many fields. In partic...

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Detalles Bibliográficos
Autores principales: Huang, Xiaohan, Ma, Yanhong, Li, Yangyang, Han, Fei, Lin, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193852/
https://www.ncbi.nlm.nih.gov/pubmed/34124026
http://dx.doi.org/10.3389/fbioe.2021.683247
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author Huang, Xiaohan
Ma, Yanhong
Li, Yangyang
Han, Fei
Lin, Weiqiang
author_facet Huang, Xiaohan
Ma, Yanhong
Li, Yangyang
Han, Fei
Lin, Weiqiang
author_sort Huang, Xiaohan
collection PubMed
description Kidney diseases have gradually become a global health burden. Along with the development of nanotechnology, many hybrids or nanomaterials have been utilized to promote treatment efficiency with negligible side effects. These therapeutic agents have been successfully applied in many fields. In particular, some efforts have also been made to ameliorate the treatment of kidney diseases through targeted delivery nanomaterials. Though most of the delivery systems have not yet been transmitted into clinical use or even still at an early stage, they have shown great potential in carrying immunosuppressants like tacrolimus and triptolide, antioxidants, or siRNAs. Excitingly, some of them have achieved significant treatment effectiveness and reduced systemic side effect in kidney disease animal models. Here, we have reviewed the recent advances and presented nanotherapeutic devices designed for kidney targeted delivery.
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spelling pubmed-81938522021-06-12 Targeted Drug Delivery Systems for Kidney Diseases Huang, Xiaohan Ma, Yanhong Li, Yangyang Han, Fei Lin, Weiqiang Front Bioeng Biotechnol Bioengineering and Biotechnology Kidney diseases have gradually become a global health burden. Along with the development of nanotechnology, many hybrids or nanomaterials have been utilized to promote treatment efficiency with negligible side effects. These therapeutic agents have been successfully applied in many fields. In particular, some efforts have also been made to ameliorate the treatment of kidney diseases through targeted delivery nanomaterials. Though most of the delivery systems have not yet been transmitted into clinical use or even still at an early stage, they have shown great potential in carrying immunosuppressants like tacrolimus and triptolide, antioxidants, or siRNAs. Excitingly, some of them have achieved significant treatment effectiveness and reduced systemic side effect in kidney disease animal models. Here, we have reviewed the recent advances and presented nanotherapeutic devices designed for kidney targeted delivery. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8193852/ /pubmed/34124026 http://dx.doi.org/10.3389/fbioe.2021.683247 Text en Copyright © 2021 Huang, Ma, Li, Han and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Huang, Xiaohan
Ma, Yanhong
Li, Yangyang
Han, Fei
Lin, Weiqiang
Targeted Drug Delivery Systems for Kidney Diseases
title Targeted Drug Delivery Systems for Kidney Diseases
title_full Targeted Drug Delivery Systems for Kidney Diseases
title_fullStr Targeted Drug Delivery Systems for Kidney Diseases
title_full_unstemmed Targeted Drug Delivery Systems for Kidney Diseases
title_short Targeted Drug Delivery Systems for Kidney Diseases
title_sort targeted drug delivery systems for kidney diseases
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193852/
https://www.ncbi.nlm.nih.gov/pubmed/34124026
http://dx.doi.org/10.3389/fbioe.2021.683247
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AT mayanhong targeteddrugdeliverysystemsforkidneydiseases
AT liyangyang targeteddrugdeliverysystemsforkidneydiseases
AT hanfei targeteddrugdeliverysystemsforkidneydiseases
AT linweiqiang targeteddrugdeliverysystemsforkidneydiseases