Cargando…

Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study

AIMS: Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes i...

Descripción completa

Detalles Bibliográficos
Autores principales: Paetzold, I., Myin-Germeys, I., Schick, A., Nelson, B., Velthorst, E., Schirmbeck, F., van Os, J., Morgan, C., Hartmann, J., van der Gaag, M., de Haan, L., Valmaggia, L., McGuire, P., Kempton, M., Reininghaus, U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193966/
https://www.ncbi.nlm.nih.gov/pubmed/34044905
http://dx.doi.org/10.1017/S2045796021000251
_version_ 1783706329230082048
author Paetzold, I.
Myin-Germeys, I.
Schick, A.
Nelson, B.
Velthorst, E.
Schirmbeck, F.
van Os, J.
Morgan, C.
Hartmann, J.
van der Gaag, M.
de Haan, L.
Valmaggia, L.
McGuire, P.
Kempton, M.
Reininghaus, U.
author_facet Paetzold, I.
Myin-Germeys, I.
Schick, A.
Nelson, B.
Velthorst, E.
Schirmbeck, F.
van Os, J.
Morgan, C.
Hartmann, J.
van der Gaag, M.
de Haan, L.
Valmaggia, L.
McGuire, P.
Kempton, M.
Reininghaus, U.
author_sort Paetzold, I.
collection PubMed
description AIMS: Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes in individuals at ultra-high-risk (UHR) for psychosis. METHODS: Experience sampling methodology was used to measure momentary stress, affect and psychotic experiences in the daily life of N = 79 UHR individuals in the EU-GEI High Risk Study. The Childhood Trauma Questionnaire was used to assess self-reported childhood trauma. Clinical outcomes were assessed at baseline, 1- and 2-year follow-up. RESULTS: The association of stress with positive (β = −0.14, p = 0.010) and negative affect (β = 0.11, p = 0.020) was modified by transition status such that stress reactivity was greater in individuals who transitioned to psychosis. Moreover, the association of stress with negative affect (β = 0.06, p = 0.019) and psychotic experiences (β = 0.05, p = 0.037) was greater in individuals exposed to high v. low levels of childhood trauma. We also found evidence that decreased positive affect in response to stress was associated with reduced functioning at 1-year follow-up (B = 6.29, p = 0.034). In addition, there was evidence that the association of childhood trauma with poor functional outcomes was mediated by stress reactivity (e.g. indirect effect: B = −2.13, p = 0.026), but no evidence that stress reactivity mediated the association between childhood trauma and transition (e.g. indirect effect: B = 0.14, p = 0.506). CONCLUSIONS: Emotional and psychotic stress reactivity may be potential mechanisms linking childhood trauma with clinical outcomes in UHR individuals.
format Online
Article
Text
id pubmed-8193966
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-81939662021-06-23 Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study Paetzold, I. Myin-Germeys, I. Schick, A. Nelson, B. Velthorst, E. Schirmbeck, F. van Os, J. Morgan, C. Hartmann, J. van der Gaag, M. de Haan, L. Valmaggia, L. McGuire, P. Kempton, M. Reininghaus, U. Epidemiol Psychiatr Sci Original Article AIMS: Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes in individuals at ultra-high-risk (UHR) for psychosis. METHODS: Experience sampling methodology was used to measure momentary stress, affect and psychotic experiences in the daily life of N = 79 UHR individuals in the EU-GEI High Risk Study. The Childhood Trauma Questionnaire was used to assess self-reported childhood trauma. Clinical outcomes were assessed at baseline, 1- and 2-year follow-up. RESULTS: The association of stress with positive (β = −0.14, p = 0.010) and negative affect (β = 0.11, p = 0.020) was modified by transition status such that stress reactivity was greater in individuals who transitioned to psychosis. Moreover, the association of stress with negative affect (β = 0.06, p = 0.019) and psychotic experiences (β = 0.05, p = 0.037) was greater in individuals exposed to high v. low levels of childhood trauma. We also found evidence that decreased positive affect in response to stress was associated with reduced functioning at 1-year follow-up (B = 6.29, p = 0.034). In addition, there was evidence that the association of childhood trauma with poor functional outcomes was mediated by stress reactivity (e.g. indirect effect: B = −2.13, p = 0.026), but no evidence that stress reactivity mediated the association between childhood trauma and transition (e.g. indirect effect: B = 0.14, p = 0.506). CONCLUSIONS: Emotional and psychotic stress reactivity may be potential mechanisms linking childhood trauma with clinical outcomes in UHR individuals. Cambridge University Press 2021-05-28 /pmc/articles/PMC8193966/ /pubmed/34044905 http://dx.doi.org/10.1017/S2045796021000251 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Article
Paetzold, I.
Myin-Germeys, I.
Schick, A.
Nelson, B.
Velthorst, E.
Schirmbeck, F.
van Os, J.
Morgan, C.
Hartmann, J.
van der Gaag, M.
de Haan, L.
Valmaggia, L.
McGuire, P.
Kempton, M.
Reininghaus, U.
Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study
title Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study
title_full Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study
title_fullStr Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study
title_full_unstemmed Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study
title_short Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study
title_sort stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: findings from the eu-gei high risk study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193966/
https://www.ncbi.nlm.nih.gov/pubmed/34044905
http://dx.doi.org/10.1017/S2045796021000251
work_keys_str_mv AT paetzoldi stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT myingermeysi stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT schicka stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT nelsonb stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT velthorste stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT schirmbeckf stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT vanosj stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT morganc stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT hartmannj stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT vandergaagm stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT dehaanl stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT valmaggial stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT mcguirep stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT kemptonm stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy
AT reininghausu stressreactivityasaputativemechanismlinkingchildhoodtraumawithclinicaloutcomesinindividualsatultrahighriskforpsychosisfindingsfromtheeugeihighriskstudy