Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration

Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4...

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Autores principales: Chen, Huating, Li, Gongchi, Liu, Yiqiong, Ji, Shuaifei, Li, Yan, Xiang, Jiangbing, Zhou, Laixian, Gao, Huanhuan, Zhang, Wenwen, Sun, Xiaoyan, Fu, Xiaobing, Li, Binghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194072/
https://www.ncbi.nlm.nih.gov/pubmed/34122427
http://dx.doi.org/10.3389/fimmu.2021.668758
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author Chen, Huating
Li, Gongchi
Liu, Yiqiong
Ji, Shuaifei
Li, Yan
Xiang, Jiangbing
Zhou, Laixian
Gao, Huanhuan
Zhang, Wenwen
Sun, Xiaoyan
Fu, Xiaobing
Li, Binghui
author_facet Chen, Huating
Li, Gongchi
Liu, Yiqiong
Ji, Shuaifei
Li, Yan
Xiang, Jiangbing
Zhou, Laixian
Gao, Huanhuan
Zhang, Wenwen
Sun, Xiaoyan
Fu, Xiaobing
Li, Binghui
author_sort Chen, Huating
collection PubMed
description Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) signaling in wound repair and regeneration. However, the molecular mechanism of regeneration is not clear. This review describes various types of tissue regeneration that CXCR4 participates in and how the efficiency of regeneration is increased by CXCR4 overexpression. It emphasizes the pleiotropic effects of CXCR4 in regeneration. By delving into the specific molecular mechanisms of CXCR4, we hope to provide a theoretical basis for tissue engineering and future regenerative medicine.
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spelling pubmed-81940722021-06-12 Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration Chen, Huating Li, Gongchi Liu, Yiqiong Ji, Shuaifei Li, Yan Xiang, Jiangbing Zhou, Laixian Gao, Huanhuan Zhang, Wenwen Sun, Xiaoyan Fu, Xiaobing Li, Binghui Front Immunol Immunology Wound healing is a multi-step process that includes multiple cellular events such as cell proliferation, cell adhesion, and chemotactic response as well as cell apoptosis. Accumulating studies have documented the significance of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) signaling in wound repair and regeneration. However, the molecular mechanism of regeneration is not clear. This review describes various types of tissue regeneration that CXCR4 participates in and how the efficiency of regeneration is increased by CXCR4 overexpression. It emphasizes the pleiotropic effects of CXCR4 in regeneration. By delving into the specific molecular mechanisms of CXCR4, we hope to provide a theoretical basis for tissue engineering and future regenerative medicine. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8194072/ /pubmed/34122427 http://dx.doi.org/10.3389/fimmu.2021.668758 Text en Copyright © 2021 Chen, Li, Liu, Ji, Li, Xiang, Zhou, Gao, Zhang, Sun, Fu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Huating
Li, Gongchi
Liu, Yiqiong
Ji, Shuaifei
Li, Yan
Xiang, Jiangbing
Zhou, Laixian
Gao, Huanhuan
Zhang, Wenwen
Sun, Xiaoyan
Fu, Xiaobing
Li, Binghui
Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
title Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
title_full Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
title_fullStr Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
title_full_unstemmed Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
title_short Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration
title_sort pleiotropic roles of cxcr4 in wound repair and regeneration
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194072/
https://www.ncbi.nlm.nih.gov/pubmed/34122427
http://dx.doi.org/10.3389/fimmu.2021.668758
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