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Pharmacokinetic Characteristics, Tissue Bioaccumulation and Toxicity Profiles of Oral Arsenic Trioxide in Rats: Implications for the Treatment and Risk Assessment of Acute Promyelocytic Leukemia

Oral arsenic trioxide (ATO) has demonstrated a favorable clinical efficiency in the treatment of acute promyelocytic leukemia (APL). However, the pharmacokinetic characteristics, tissue bioaccumulation, and toxicity profiles of arsenic metabolites in vivo following oral administration of ATO have no...

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Detalles Bibliográficos
Autores principales:	Liu, Wensheng, Wang, Bin, Zhao, Yilei, Wu, Zhiqiang, Dong, Andi, Chen, Hongzhu, Lin, Liwang, Lu, Jing, Hai, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194082/ https://www.ncbi.nlm.nih.gov/pubmed/34122070 http://dx.doi.org/10.3389/fphar.2021.647687

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