Extrachromosomal circular DNA: a new potential role in cancer progression

Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) ac...

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Autores principales: Wang, Tianyi, Zhang, Haijian, Zhou, Youlang, Shi, Jiahai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194206/
https://www.ncbi.nlm.nih.gov/pubmed/34112178
http://dx.doi.org/10.1186/s12967-021-02927-x
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author Wang, Tianyi
Zhang, Haijian
Zhou, Youlang
Shi, Jiahai
author_facet Wang, Tianyi
Zhang, Haijian
Zhou, Youlang
Shi, Jiahai
author_sort Wang, Tianyi
collection PubMed
description Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) according to its size and sequence. Multiple studies have shown that eccDNA is the product of genomic instability, has rich and important biological functions, and is involved in the occurrence of many diseases, including cancer. In this review, we focus on the discovery history, formation process, characteristics, and physiological functions of eccDNAs; the potential functions of various eccDNAs in human cancer; and the research methods employed to study eccDNA.
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spelling pubmed-81942062021-06-15 Extrachromosomal circular DNA: a new potential role in cancer progression Wang, Tianyi Zhang, Haijian Zhou, Youlang Shi, Jiahai J Transl Med Review Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) according to its size and sequence. Multiple studies have shown that eccDNA is the product of genomic instability, has rich and important biological functions, and is involved in the occurrence of many diseases, including cancer. In this review, we focus on the discovery history, formation process, characteristics, and physiological functions of eccDNAs; the potential functions of various eccDNAs in human cancer; and the research methods employed to study eccDNA. BioMed Central 2021-06-10 /pmc/articles/PMC8194206/ /pubmed/34112178 http://dx.doi.org/10.1186/s12967-021-02927-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Tianyi
Zhang, Haijian
Zhou, Youlang
Shi, Jiahai
Extrachromosomal circular DNA: a new potential role in cancer progression
title Extrachromosomal circular DNA: a new potential role in cancer progression
title_full Extrachromosomal circular DNA: a new potential role in cancer progression
title_fullStr Extrachromosomal circular DNA: a new potential role in cancer progression
title_full_unstemmed Extrachromosomal circular DNA: a new potential role in cancer progression
title_short Extrachromosomal circular DNA: a new potential role in cancer progression
title_sort extrachromosomal circular dna: a new potential role in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194206/
https://www.ncbi.nlm.nih.gov/pubmed/34112178
http://dx.doi.org/10.1186/s12967-021-02927-x
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