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The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapi...

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Autores principales: Shams, Shahin, Martinez, Joseph M., Dawson, John R. D., Flores, Juan, Gabriel, Marina, Garcia, Gustavo, Guevara, Amanda, Murray, Kaitlin, Pacifici, Noah, Vargas, Maxemiliano V., Voelker, Taylor, Hell, Johannes W., Ashouri, Judith F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194305/
https://www.ncbi.nlm.nih.gov/pubmed/34122106
http://dx.doi.org/10.3389/fphar.2021.680043
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author Shams, Shahin
Martinez, Joseph M.
Dawson, John R. D.
Flores, Juan
Gabriel, Marina
Garcia, Gustavo
Guevara, Amanda
Murray, Kaitlin
Pacifici, Noah
Vargas, Maxemiliano V.
Voelker, Taylor
Hell, Johannes W.
Ashouri, Judith F.
author_facet Shams, Shahin
Martinez, Joseph M.
Dawson, John R. D.
Flores, Juan
Gabriel, Marina
Garcia, Gustavo
Guevara, Amanda
Murray, Kaitlin
Pacifici, Noah
Vargas, Maxemiliano V.
Voelker, Taylor
Hell, Johannes W.
Ashouri, Judith F.
author_sort Shams, Shahin
collection PubMed
description Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapies, or intolerable side effects, with resultant progression of their disease. In this review, we detail multiple biomolecular pathways involved in RA disease pathogenesis to elucidate and highlight pathways that have been therapeutic targets in managing this systemic autoimmune disease. Here we present an up-to-date accounting of both emerging and approved pharmacological treatments for RA, detailing their discovery, mechanisms of action, efficacy, and limitations. Finally, we turn to the emerging fields of bioengineering and cell therapy to illuminate possible future targeted therapeutic options that combine material and biological sciences for localized therapeutic action with the potential to greatly reduce side effects seen in systemically applied treatment modalities.
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spelling pubmed-81943052021-06-12 The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions Shams, Shahin Martinez, Joseph M. Dawson, John R. D. Flores, Juan Gabriel, Marina Garcia, Gustavo Guevara, Amanda Murray, Kaitlin Pacifici, Noah Vargas, Maxemiliano V. Voelker, Taylor Hell, Johannes W. Ashouri, Judith F. Front Pharmacol Pharmacology Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapies, or intolerable side effects, with resultant progression of their disease. In this review, we detail multiple biomolecular pathways involved in RA disease pathogenesis to elucidate and highlight pathways that have been therapeutic targets in managing this systemic autoimmune disease. Here we present an up-to-date accounting of both emerging and approved pharmacological treatments for RA, detailing their discovery, mechanisms of action, efficacy, and limitations. Finally, we turn to the emerging fields of bioengineering and cell therapy to illuminate possible future targeted therapeutic options that combine material and biological sciences for localized therapeutic action with the potential to greatly reduce side effects seen in systemically applied treatment modalities. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8194305/ /pubmed/34122106 http://dx.doi.org/10.3389/fphar.2021.680043 Text en Copyright © 2021 Shams, Martinez, Dawson, Flores, Gabriel, Garcia, Guevara, Murray, Pacifici, Vargas, Voelker, Hell and Ashouri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Shams, Shahin
Martinez, Joseph M.
Dawson, John R. D.
Flores, Juan
Gabriel, Marina
Garcia, Gustavo
Guevara, Amanda
Murray, Kaitlin
Pacifici, Noah
Vargas, Maxemiliano V.
Voelker, Taylor
Hell, Johannes W.
Ashouri, Judith F.
The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions
title The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions
title_full The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions
title_fullStr The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions
title_full_unstemmed The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions
title_short The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions
title_sort therapeutic landscape of rheumatoid arthritis: current state and future directions
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194305/
https://www.ncbi.nlm.nih.gov/pubmed/34122106
http://dx.doi.org/10.3389/fphar.2021.680043
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