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The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194305/ https://www.ncbi.nlm.nih.gov/pubmed/34122106 http://dx.doi.org/10.3389/fphar.2021.680043 |
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author | Shams, Shahin Martinez, Joseph M. Dawson, John R. D. Flores, Juan Gabriel, Marina Garcia, Gustavo Guevara, Amanda Murray, Kaitlin Pacifici, Noah Vargas, Maxemiliano V. Voelker, Taylor Hell, Johannes W. Ashouri, Judith F. |
author_facet | Shams, Shahin Martinez, Joseph M. Dawson, John R. D. Flores, Juan Gabriel, Marina Garcia, Gustavo Guevara, Amanda Murray, Kaitlin Pacifici, Noah Vargas, Maxemiliano V. Voelker, Taylor Hell, Johannes W. Ashouri, Judith F. |
author_sort | Shams, Shahin |
collection | PubMed |
description | Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapies, or intolerable side effects, with resultant progression of their disease. In this review, we detail multiple biomolecular pathways involved in RA disease pathogenesis to elucidate and highlight pathways that have been therapeutic targets in managing this systemic autoimmune disease. Here we present an up-to-date accounting of both emerging and approved pharmacological treatments for RA, detailing their discovery, mechanisms of action, efficacy, and limitations. Finally, we turn to the emerging fields of bioengineering and cell therapy to illuminate possible future targeted therapeutic options that combine material and biological sciences for localized therapeutic action with the potential to greatly reduce side effects seen in systemically applied treatment modalities. |
format | Online Article Text |
id | pubmed-8194305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81943052021-06-12 The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions Shams, Shahin Martinez, Joseph M. Dawson, John R. D. Flores, Juan Gabriel, Marina Garcia, Gustavo Guevara, Amanda Murray, Kaitlin Pacifici, Noah Vargas, Maxemiliano V. Voelker, Taylor Hell, Johannes W. Ashouri, Judith F. Front Pharmacol Pharmacology Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with RA continue to have inadequate response to therapies, or intolerable side effects, with resultant progression of their disease. In this review, we detail multiple biomolecular pathways involved in RA disease pathogenesis to elucidate and highlight pathways that have been therapeutic targets in managing this systemic autoimmune disease. Here we present an up-to-date accounting of both emerging and approved pharmacological treatments for RA, detailing their discovery, mechanisms of action, efficacy, and limitations. Finally, we turn to the emerging fields of bioengineering and cell therapy to illuminate possible future targeted therapeutic options that combine material and biological sciences for localized therapeutic action with the potential to greatly reduce side effects seen in systemically applied treatment modalities. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8194305/ /pubmed/34122106 http://dx.doi.org/10.3389/fphar.2021.680043 Text en Copyright © 2021 Shams, Martinez, Dawson, Flores, Gabriel, Garcia, Guevara, Murray, Pacifici, Vargas, Voelker, Hell and Ashouri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Shams, Shahin Martinez, Joseph M. Dawson, John R. D. Flores, Juan Gabriel, Marina Garcia, Gustavo Guevara, Amanda Murray, Kaitlin Pacifici, Noah Vargas, Maxemiliano V. Voelker, Taylor Hell, Johannes W. Ashouri, Judith F. The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions |
title | The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions |
title_full | The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions |
title_fullStr | The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions |
title_full_unstemmed | The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions |
title_short | The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions |
title_sort | therapeutic landscape of rheumatoid arthritis: current state and future directions |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194305/ https://www.ncbi.nlm.nih.gov/pubmed/34122106 http://dx.doi.org/10.3389/fphar.2021.680043 |
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