First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19

Urine 11-dehydro-thromboxane B(2) (u11-dh-TxB(2)), 8-hydroxy-2’-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB(2) an...

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Autores principales: Tantry, Udaya S, Bliden, Kevin P, Cho, Alastair, Walia, Naval, Dahlen, Jeffrey R, Ens, Gordon, Traianova, Malina, Jerjian, Christophe, Usman, Abira, Gurbel, Paul A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194603/
https://www.ncbi.nlm.nih.gov/pubmed/34250193
http://dx.doi.org/10.1093/ofid/ofab274
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author Tantry, Udaya S
Bliden, Kevin P
Cho, Alastair
Walia, Naval
Dahlen, Jeffrey R
Ens, Gordon
Traianova, Malina
Jerjian, Christophe
Usman, Abira
Gurbel, Paul A
author_facet Tantry, Udaya S
Bliden, Kevin P
Cho, Alastair
Walia, Naval
Dahlen, Jeffrey R
Ens, Gordon
Traianova, Malina
Jerjian, Christophe
Usman, Abira
Gurbel, Paul A
author_sort Tantry, Udaya S
collection PubMed
description Urine 11-dehydro-thromboxane B(2) (u11-dh-TxB(2)), 8-hydroxy-2’-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB(2) and L-FABP levels were associated with longer hospitalization, more thrombotic events, and greater mortality, providing evidence for potential utility as early prognostic biomarkers for COVID-19.
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spelling pubmed-81946032021-06-15 First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19 Tantry, Udaya S Bliden, Kevin P Cho, Alastair Walia, Naval Dahlen, Jeffrey R Ens, Gordon Traianova, Malina Jerjian, Christophe Usman, Abira Gurbel, Paul A Open Forum Infect Dis Brief Report Urine 11-dehydro-thromboxane B(2) (u11-dh-TxB(2)), 8-hydroxy-2’-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB(2) and L-FABP levels were associated with longer hospitalization, more thrombotic events, and greater mortality, providing evidence for potential utility as early prognostic biomarkers for COVID-19. Oxford University Press 2021-05-26 /pmc/articles/PMC8194603/ /pubmed/34250193 http://dx.doi.org/10.1093/ofid/ofab274 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Tantry, Udaya S
Bliden, Kevin P
Cho, Alastair
Walia, Naval
Dahlen, Jeffrey R
Ens, Gordon
Traianova, Malina
Jerjian, Christophe
Usman, Abira
Gurbel, Paul A
First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
title First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
title_full First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
title_fullStr First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
title_full_unstemmed First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
title_short First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
title_sort first experience addressing the prognostic utility of novel urinary biomarkers in patients with covid-19
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194603/
https://www.ncbi.nlm.nih.gov/pubmed/34250193
http://dx.doi.org/10.1093/ofid/ofab274
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