Cargando…

Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis

The objective of this study was to evaluate the effects of oral fish cartilage hydrolysate (FCH) on symptoms and joint tissue structure in rat developing osteoarthritis induced surgically. Osteoarthritis was induced in the right knee of mature male Lewis rats (n = 12/group) by surgical transection o...

Descripción completa

Detalles Bibliográficos
Autores principales: Henrotin, Yves, Antoine, Christophe, Zwerts, Elodie, Neutelings, Thibaut, Bouvret, Elodie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194757/
https://www.ncbi.nlm.nih.gov/pubmed/34136155
http://dx.doi.org/10.1002/fsn3.2244
_version_ 1783706440384380928
author Henrotin, Yves
Antoine, Christophe
Zwerts, Elodie
Neutelings, Thibaut
Bouvret, Elodie
author_facet Henrotin, Yves
Antoine, Christophe
Zwerts, Elodie
Neutelings, Thibaut
Bouvret, Elodie
author_sort Henrotin, Yves
collection PubMed
description The objective of this study was to evaluate the effects of oral fish cartilage hydrolysate (FCH) on symptoms and joint tissue structure in rat developing osteoarthritis induced surgically. Osteoarthritis was induced in the right knee of mature male Lewis rats (n = 12/group) by surgical transection of the anterior cruciate ligament (ACLT) combined with partial medial meniscectomy (pMMx). Two weeks after surgery, rats were treated orally with either control (sterile H(2)O) or FCH for four weeks. Pain and function were assessed by dynamic weight‐bearing test (incapacitance test), electronic Von Frey (EVF; hindpaw allodynia threshold), and pressure algometer (knee allodynia threshold). Time and groups differences at each time point were evaluated using a mixed model. The histological features were evaluated eight weeks after surgery using OARSI score. Mann–Whitney test nonparametric test was applied to compare OARSI score. ACTL/pMMx surgery significantly reduced weight‐bearing and increased allodynia and sensitivity thresholds of the operated paw/knee. Globally, FCH improved these parameters faster, but no significant difference between control and FCH groups was observed. Eight weeks after surgery, rats developed moderate OA lesions. Compared with control, FCH did not significantly modify OA lesion severity assessed using the OARSI score. In this mechanically induced OA model, 4 weeks of supplementation with FCH had no significant effect on cartilage lesion, but tends to accelerate pain relief and joint function recovery. This positive trend may have opened the way for further investigation of FCH as potential treatment of joint discomfort associated with OA.
format Online
Article
Text
id pubmed-8194757
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-81947572021-06-15 Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis Henrotin, Yves Antoine, Christophe Zwerts, Elodie Neutelings, Thibaut Bouvret, Elodie Food Sci Nutr Original Research The objective of this study was to evaluate the effects of oral fish cartilage hydrolysate (FCH) on symptoms and joint tissue structure in rat developing osteoarthritis induced surgically. Osteoarthritis was induced in the right knee of mature male Lewis rats (n = 12/group) by surgical transection of the anterior cruciate ligament (ACLT) combined with partial medial meniscectomy (pMMx). Two weeks after surgery, rats were treated orally with either control (sterile H(2)O) or FCH for four weeks. Pain and function were assessed by dynamic weight‐bearing test (incapacitance test), electronic Von Frey (EVF; hindpaw allodynia threshold), and pressure algometer (knee allodynia threshold). Time and groups differences at each time point were evaluated using a mixed model. The histological features were evaluated eight weeks after surgery using OARSI score. Mann–Whitney test nonparametric test was applied to compare OARSI score. ACTL/pMMx surgery significantly reduced weight‐bearing and increased allodynia and sensitivity thresholds of the operated paw/knee. Globally, FCH improved these parameters faster, but no significant difference between control and FCH groups was observed. Eight weeks after surgery, rats developed moderate OA lesions. Compared with control, FCH did not significantly modify OA lesion severity assessed using the OARSI score. In this mechanically induced OA model, 4 weeks of supplementation with FCH had no significant effect on cartilage lesion, but tends to accelerate pain relief and joint function recovery. This positive trend may have opened the way for further investigation of FCH as potential treatment of joint discomfort associated with OA. John Wiley and Sons Inc. 2021-04-10 /pmc/articles/PMC8194757/ /pubmed/34136155 http://dx.doi.org/10.1002/fsn3.2244 Text en © 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Henrotin, Yves
Antoine, Christophe
Zwerts, Elodie
Neutelings, Thibaut
Bouvret, Elodie
Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
title Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
title_full Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
title_fullStr Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
title_full_unstemmed Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
title_short Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
title_sort oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194757/
https://www.ncbi.nlm.nih.gov/pubmed/34136155
http://dx.doi.org/10.1002/fsn3.2244
work_keys_str_mv AT henrotinyves oralsupplementationwithfishcartilagehydrolysateacceleratesjointfunctionrecoveryinratmodeloftraumatickneeosteoarthritis
AT antoinechristophe oralsupplementationwithfishcartilagehydrolysateacceleratesjointfunctionrecoveryinratmodeloftraumatickneeosteoarthritis
AT zwertselodie oralsupplementationwithfishcartilagehydrolysateacceleratesjointfunctionrecoveryinratmodeloftraumatickneeosteoarthritis
AT neutelingsthibaut oralsupplementationwithfishcartilagehydrolysateacceleratesjointfunctionrecoveryinratmodeloftraumatickneeosteoarthritis
AT bouvretelodie oralsupplementationwithfishcartilagehydrolysateacceleratesjointfunctionrecoveryinratmodeloftraumatickneeosteoarthritis