NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4 (PAD4), the role of the NLRP3 inflammasome in...

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Detalles Bibliográficos
Autores principales: Münzer, Patrick, Negro, Roberto, Fukui, Shoichi, di Meglio, Lucas, Aymonnier, Karen, Chu, Long, Cherpokova, Deya, Gutch, Sarah, Sorvillo, Nicoletta, Shi, Lai, Magupalli, Venkat Giri, Weber, Alexander N. R., Scharf, Rüdiger E., Waterman, Clare M., Wu, Hao, Wagner, Denisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195330/
https://www.ncbi.nlm.nih.gov/pubmed/34122445
http://dx.doi.org/10.3389/fimmu.2021.683803

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