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Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195391/ https://www.ncbi.nlm.nih.gov/pubmed/34061841 http://dx.doi.org/10.1371/journal.pntd.0009452 |
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author | Kajihara, Masahiro Simuunza, Martin Saasa, Ngonda Dautu, George Mori-Kajihara, Akina Qiu, Yongjin Nakao, Ryo Eto, Yoshiki Furumoto, Hayato Hang’ombe, Bernard M. Orba, Yasuko Sawa, Hirofumi Simulundu, Edgar Fukushi, Shuetsu Morikawa, Shigeru Saijo, Masayuki Arikawa, Jiro Kabilika, Swithine Monze, Mwaka Mukonka, Victor Mweene, Aaron Takada, Ayato Yoshimatsu, Kumiko |
author_facet | Kajihara, Masahiro Simuunza, Martin Saasa, Ngonda Dautu, George Mori-Kajihara, Akina Qiu, Yongjin Nakao, Ryo Eto, Yoshiki Furumoto, Hayato Hang’ombe, Bernard M. Orba, Yasuko Sawa, Hirofumi Simulundu, Edgar Fukushi, Shuetsu Morikawa, Shigeru Saijo, Masayuki Arikawa, Jiro Kabilika, Swithine Monze, Mwaka Mukonka, Victor Mweene, Aaron Takada, Ayato Yoshimatsu, Kumiko |
author_sort | Kajihara, Masahiro |
collection | PubMed |
description | Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts. |
format | Online Article Text |
id | pubmed-8195391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81953912021-06-21 Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia Kajihara, Masahiro Simuunza, Martin Saasa, Ngonda Dautu, George Mori-Kajihara, Akina Qiu, Yongjin Nakao, Ryo Eto, Yoshiki Furumoto, Hayato Hang’ombe, Bernard M. Orba, Yasuko Sawa, Hirofumi Simulundu, Edgar Fukushi, Shuetsu Morikawa, Shigeru Saijo, Masayuki Arikawa, Jiro Kabilika, Swithine Monze, Mwaka Mukonka, Victor Mweene, Aaron Takada, Ayato Yoshimatsu, Kumiko PLoS Negl Trop Dis Research Article Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonosis with a high case fatality rate in humans. Although the disease is widely found in Africa, Europe, and Asia, the distribution and genetic diversity of CCHF virus (CCHFV) are poorly understood in African countries. To assess the risks of CCHF in Zambia, where CCHF has never been reported, epidemiologic studies in cattle and ticks were conducted. Through an indirect immunofluorescence assay, CCHFV nucleoprotein-specific serum IgG was detected in 8.4% (88/1,047) of cattle. Among 290 Hyalomma ticks, the principal vector of CCHFV, the viral genome was detected in 11 ticks. Phylogenetic analyses of the CCHFV S and M genome segments revealed that one of the detected viruses was a genetic reassortant between African and Asian strains. This study provides compelling evidence for the presence of CCHFV in Zambia and its transmission to vertebrate hosts. Public Library of Science 2021-06-01 /pmc/articles/PMC8195391/ /pubmed/34061841 http://dx.doi.org/10.1371/journal.pntd.0009452 Text en © 2021 Kajihara et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kajihara, Masahiro Simuunza, Martin Saasa, Ngonda Dautu, George Mori-Kajihara, Akina Qiu, Yongjin Nakao, Ryo Eto, Yoshiki Furumoto, Hayato Hang’ombe, Bernard M. Orba, Yasuko Sawa, Hirofumi Simulundu, Edgar Fukushi, Shuetsu Morikawa, Shigeru Saijo, Masayuki Arikawa, Jiro Kabilika, Swithine Monze, Mwaka Mukonka, Victor Mweene, Aaron Takada, Ayato Yoshimatsu, Kumiko Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia |
title | Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia |
title_full | Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia |
title_fullStr | Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia |
title_full_unstemmed | Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia |
title_short | Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia |
title_sort | serologic and molecular evidence for circulation of crimean-congo hemorrhagic fever virus in ticks and cattle in zambia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195391/ https://www.ncbi.nlm.nih.gov/pubmed/34061841 http://dx.doi.org/10.1371/journal.pntd.0009452 |
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