HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes

Chemicals reactivating epigenetically silenced genes target diverse classes of enzymes, including DNMTs, HDACs, HMTs and BET protein family members. They can strongly influence the expression of genes and endogenous retroviral elements with concomitant dsRNA synthesis and massive transcription of LT...

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Detalles Bibliográficos
Autores principales: Maksimova, Varvara, Shalginskikh, Natalya, Vlasova, Olga, Usalka, Olga, Beizer, Anastasia, Bugaeva, Polina, Fedorov, Dmitry, Lizogub, Olga, Lesovaya, Ekaterina, Katz, Richard, Belitsky, Gennady, Kirsanov, Kirill, Yakubovskaya, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195432/
https://www.ncbi.nlm.nih.gov/pubmed/34115770
http://dx.doi.org/10.1371/journal.pone.0252504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195432/
https://www.ncbi.nlm.nih.gov/pubmed/34115770
http://dx.doi.org/10.1371/journal.pone.0252504

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