Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

The transcription factors T-bet and Eomesodermin (Eomes) regulate CD8 T cell exhaustion through undefined mechanisms. Here, we show that the subcellular localization of T-bet and Eomes dictate their regulatory activity in exhausted T cells (T(EX)s). T(EX)s had a higher ratio of nuclear Eomes:T-bet t...

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Detalles Bibliográficos
Autores principales: McLane, Laura M., Ngiow, Shin Foong, Chen, Zeyu, Attanasio, John, Manne, Sasikanth, Ruthel, Gordon, Wu, Jennifer E., Staupe, Ryan P., Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Freedman, Bruce D., Betts, Michael R., Wherry, E. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195461/
https://www.ncbi.nlm.nih.gov/pubmed/33979613
http://dx.doi.org/10.1016/j.celrep.2021.109120

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