Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion

The revolutionizing efficacy of recombinant human bone morphogenetic protein (rhBMP-2) for clinical spinal fusion is hindered by safety issues associated with the high dose required. However, it continues to be widely used, for example, in InFUSE Bone Graft (Medtronic). Here, we developed a translat...

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Detalles Bibliográficos
Autores principales: Briquez, Priscilla S., Tsai, Hsiu-Ming, Watkins, Elyse A., Hubbell, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195475/
https://www.ncbi.nlm.nih.gov/pubmed/34117071
http://dx.doi.org/10.1126/sciadv.abh4302

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