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Vitamin D deficiency exacerbates UV/endorphin and opioid addiction

The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of...

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Autores principales: Kemény, Lajos V., Robinson, Kathleen C., Hermann, Andrea L., Walker, Deena M., Regan, Susan, Yew, Yik Weng, Lai, Yi Chun, Theodosakis, Nicholas, Rivera, Phillip D., Ding, Weihua, Yang, Liuyue, Beyer, Tobias, Loh, Yong-Hwee E., Lo, Jennifer A., van der Sande, Anita A. J., Sarnie, William, Kotler, David, Hsiao, Jennifer J., Su, Mack Y., Kato, Shinichiro, Kotler, Joseph, Bilbo, Staci D., Chopra, Vanita, Salomon, Matthew P., Shen, Shiqian, Hoon, Dave S. B., Asgari, Maryam M., Wakeman, Sarah E., Nestler, Eric J., Fisher, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195487/
https://www.ncbi.nlm.nih.gov/pubmed/34117054
http://dx.doi.org/10.1126/sciadv.abe4577
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author Kemény, Lajos V.
Robinson, Kathleen C.
Hermann, Andrea L.
Walker, Deena M.
Regan, Susan
Yew, Yik Weng
Lai, Yi Chun
Theodosakis, Nicholas
Rivera, Phillip D.
Ding, Weihua
Yang, Liuyue
Beyer, Tobias
Loh, Yong-Hwee E.
Lo, Jennifer A.
van der Sande, Anita A. J.
Sarnie, William
Kotler, David
Hsiao, Jennifer J.
Su, Mack Y.
Kato, Shinichiro
Kotler, Joseph
Bilbo, Staci D.
Chopra, Vanita
Salomon, Matthew P.
Shen, Shiqian
Hoon, Dave S. B.
Asgari, Maryam M.
Wakeman, Sarah E.
Nestler, Eric J.
Fisher, David E.
author_facet Kemény, Lajos V.
Robinson, Kathleen C.
Hermann, Andrea L.
Walker, Deena M.
Regan, Susan
Yew, Yik Weng
Lai, Yi Chun
Theodosakis, Nicholas
Rivera, Phillip D.
Ding, Weihua
Yang, Liuyue
Beyer, Tobias
Loh, Yong-Hwee E.
Lo, Jennifer A.
van der Sande, Anita A. J.
Sarnie, William
Kotler, David
Hsiao, Jennifer J.
Su, Mack Y.
Kato, Shinichiro
Kotler, Joseph
Bilbo, Staci D.
Chopra, Vanita
Salomon, Matthew P.
Shen, Shiqian
Hoon, Dave S. B.
Asgari, Maryam M.
Wakeman, Sarah E.
Nestler, Eric J.
Fisher, David E.
author_sort Kemény, Lajos V.
collection PubMed
description The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Similarly, physiologic endogenous opioid analgesia and reward responses triggered by ultraviolet (UV) radiation are repressed by VitD signaling, suggesting that a feedback loop exists whereby VitD deficiency produces increased UV/endorphin-seeking behavior until VitD levels are restored by cutaneous VitD synthesis. This feedback may carry the evolutionary advantage of maximizing VitD synthesis. However, unlike UV exposure, exogenous opioid use is not followed by VitD synthesis (and its opioid suppressive effects), contributing to maladaptive addictive behavior.
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spelling pubmed-81954872021-06-24 Vitamin D deficiency exacerbates UV/endorphin and opioid addiction Kemény, Lajos V. Robinson, Kathleen C. Hermann, Andrea L. Walker, Deena M. Regan, Susan Yew, Yik Weng Lai, Yi Chun Theodosakis, Nicholas Rivera, Phillip D. Ding, Weihua Yang, Liuyue Beyer, Tobias Loh, Yong-Hwee E. Lo, Jennifer A. van der Sande, Anita A. J. Sarnie, William Kotler, David Hsiao, Jennifer J. Su, Mack Y. Kato, Shinichiro Kotler, Joseph Bilbo, Staci D. Chopra, Vanita Salomon, Matthew P. Shen, Shiqian Hoon, Dave S. B. Asgari, Maryam M. Wakeman, Sarah E. Nestler, Eric J. Fisher, David E. Sci Adv Research Articles The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Similarly, physiologic endogenous opioid analgesia and reward responses triggered by ultraviolet (UV) radiation are repressed by VitD signaling, suggesting that a feedback loop exists whereby VitD deficiency produces increased UV/endorphin-seeking behavior until VitD levels are restored by cutaneous VitD synthesis. This feedback may carry the evolutionary advantage of maximizing VitD synthesis. However, unlike UV exposure, exogenous opioid use is not followed by VitD synthesis (and its opioid suppressive effects), contributing to maladaptive addictive behavior. American Association for the Advancement of Science 2021-06-11 /pmc/articles/PMC8195487/ /pubmed/34117054 http://dx.doi.org/10.1126/sciadv.abe4577 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Kemény, Lajos V.
Robinson, Kathleen C.
Hermann, Andrea L.
Walker, Deena M.
Regan, Susan
Yew, Yik Weng
Lai, Yi Chun
Theodosakis, Nicholas
Rivera, Phillip D.
Ding, Weihua
Yang, Liuyue
Beyer, Tobias
Loh, Yong-Hwee E.
Lo, Jennifer A.
van der Sande, Anita A. J.
Sarnie, William
Kotler, David
Hsiao, Jennifer J.
Su, Mack Y.
Kato, Shinichiro
Kotler, Joseph
Bilbo, Staci D.
Chopra, Vanita
Salomon, Matthew P.
Shen, Shiqian
Hoon, Dave S. B.
Asgari, Maryam M.
Wakeman, Sarah E.
Nestler, Eric J.
Fisher, David E.
Vitamin D deficiency exacerbates UV/endorphin and opioid addiction
title Vitamin D deficiency exacerbates UV/endorphin and opioid addiction
title_full Vitamin D deficiency exacerbates UV/endorphin and opioid addiction
title_fullStr Vitamin D deficiency exacerbates UV/endorphin and opioid addiction
title_full_unstemmed Vitamin D deficiency exacerbates UV/endorphin and opioid addiction
title_short Vitamin D deficiency exacerbates UV/endorphin and opioid addiction
title_sort vitamin d deficiency exacerbates uv/endorphin and opioid addiction
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195487/
https://www.ncbi.nlm.nih.gov/pubmed/34117054
http://dx.doi.org/10.1126/sciadv.abe4577
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