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Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border
Uruguay is one of the few countries in the Americas that successfully contained the coronavirus disease 19 (COVID-19) epidemic during the first half of 2020. Nevertheless, the intensive human mobility across the dry border with Brazil is a major challenge for public health authorities. We aimed to i...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195593/ https://www.ncbi.nlm.nih.gov/pubmed/34122369 http://dx.doi.org/10.3389/fmicb.2021.653986 |
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author | Mir, Daiana Rego, Natalia Resende, Paola Cristina Tort, Fernando Fernández-Calero, Tamara Noya, Verónica Brandes, Mariana Possi, Tania Arleo, Mailen Reyes, Natalia Victoria, Matías Lizasoain, Andres Castells, Matías Maya, Leticia Salvo, Matías Schäffer Gregianini, Tatiana Mar da Rosa, Marilda Tereza Garay Martins, Letícia Alonso, Cecilia Vega, Yasser Salazar, Cecilia Ferrés, Ignacio Smircich, Pablo Sotelo Silveira, Jose Fort, Rafael Sebastián Mathó, Cecilia Arantes, Ighor Appolinario, Luciana Mendonça, Ana Carolina Benítez-Galeano, María José Simoes, Camila Graña, Martín Motta, Fernando Siqueira, Marilda Mendonça Bello, Gonzalo Colina, Rodney Spangenberg, Lucía |
author_facet | Mir, Daiana Rego, Natalia Resende, Paola Cristina Tort, Fernando Fernández-Calero, Tamara Noya, Verónica Brandes, Mariana Possi, Tania Arleo, Mailen Reyes, Natalia Victoria, Matías Lizasoain, Andres Castells, Matías Maya, Leticia Salvo, Matías Schäffer Gregianini, Tatiana Mar da Rosa, Marilda Tereza Garay Martins, Letícia Alonso, Cecilia Vega, Yasser Salazar, Cecilia Ferrés, Ignacio Smircich, Pablo Sotelo Silveira, Jose Fort, Rafael Sebastián Mathó, Cecilia Arantes, Ighor Appolinario, Luciana Mendonça, Ana Carolina Benítez-Galeano, María José Simoes, Camila Graña, Martín Motta, Fernando Siqueira, Marilda Mendonça Bello, Gonzalo Colina, Rodney Spangenberg, Lucía |
author_sort | Mir, Daiana |
collection | PubMed |
description | Uruguay is one of the few countries in the Americas that successfully contained the coronavirus disease 19 (COVID-19) epidemic during the first half of 2020. Nevertheless, the intensive human mobility across the dry border with Brazil is a major challenge for public health authorities. We aimed to investigate the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains detected in Uruguayan localities bordering Brazil as well as to measure the viral flux across this ∼1,100 km uninterrupted dry frontier. Using complete SARS-CoV-2 genomes from the Uruguayan–Brazilian bordering region and phylogeographic analyses, we inferred the virus dissemination frequency between Brazil and Uruguay and characterized local outbreak dynamics during the first months (May–July) of the pandemic. Phylogenetic analyses revealed multiple introductions of SARS-CoV-2 Brazilian lineages B.1.1.28 and B.1.1.33 into Uruguayan localities at the bordering region. The most probable sources of viral strains introduced to Uruguay were the Southeast Brazilian region and the state of Rio Grande do Sul. Some of the viral strains introduced in Uruguayan border localities between early May and mid-July were able to locally spread and originated the first outbreaks detected outside the metropolitan region. The viral lineages responsible for Uruguayan urban outbreaks were defined by a set of between four and 11 mutations (synonymous and non-synonymous) with respect to the ancestral B.1.1.28 and B.1.1.33 viruses that arose in Brazil, supporting the notion of a rapid genetic differentiation between SARS-CoV-2 subpopulations spreading in South America. Although Uruguayan borders have remained essentially closed to non-Uruguayan citizens, the inevitable flow of people across the dry border with Brazil allowed the repeated entry of the virus into Uruguay and the subsequent emergence of local outbreaks in Uruguayan border localities. Implementation of coordinated bi-national surveillance systems is crucial to achieve an efficient control of the SARS-CoV-2 spread across this kind of highly permeable borderland regions around the world. |
format | Online Article Text |
id | pubmed-8195593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81955932021-06-12 Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border Mir, Daiana Rego, Natalia Resende, Paola Cristina Tort, Fernando Fernández-Calero, Tamara Noya, Verónica Brandes, Mariana Possi, Tania Arleo, Mailen Reyes, Natalia Victoria, Matías Lizasoain, Andres Castells, Matías Maya, Leticia Salvo, Matías Schäffer Gregianini, Tatiana Mar da Rosa, Marilda Tereza Garay Martins, Letícia Alonso, Cecilia Vega, Yasser Salazar, Cecilia Ferrés, Ignacio Smircich, Pablo Sotelo Silveira, Jose Fort, Rafael Sebastián Mathó, Cecilia Arantes, Ighor Appolinario, Luciana Mendonça, Ana Carolina Benítez-Galeano, María José Simoes, Camila Graña, Martín Motta, Fernando Siqueira, Marilda Mendonça Bello, Gonzalo Colina, Rodney Spangenberg, Lucía Front Microbiol Microbiology Uruguay is one of the few countries in the Americas that successfully contained the coronavirus disease 19 (COVID-19) epidemic during the first half of 2020. Nevertheless, the intensive human mobility across the dry border with Brazil is a major challenge for public health authorities. We aimed to investigate the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains detected in Uruguayan localities bordering Brazil as well as to measure the viral flux across this ∼1,100 km uninterrupted dry frontier. Using complete SARS-CoV-2 genomes from the Uruguayan–Brazilian bordering region and phylogeographic analyses, we inferred the virus dissemination frequency between Brazil and Uruguay and characterized local outbreak dynamics during the first months (May–July) of the pandemic. Phylogenetic analyses revealed multiple introductions of SARS-CoV-2 Brazilian lineages B.1.1.28 and B.1.1.33 into Uruguayan localities at the bordering region. The most probable sources of viral strains introduced to Uruguay were the Southeast Brazilian region and the state of Rio Grande do Sul. Some of the viral strains introduced in Uruguayan border localities between early May and mid-July were able to locally spread and originated the first outbreaks detected outside the metropolitan region. The viral lineages responsible for Uruguayan urban outbreaks were defined by a set of between four and 11 mutations (synonymous and non-synonymous) with respect to the ancestral B.1.1.28 and B.1.1.33 viruses that arose in Brazil, supporting the notion of a rapid genetic differentiation between SARS-CoV-2 subpopulations spreading in South America. Although Uruguayan borders have remained essentially closed to non-Uruguayan citizens, the inevitable flow of people across the dry border with Brazil allowed the repeated entry of the virus into Uruguay and the subsequent emergence of local outbreaks in Uruguayan border localities. Implementation of coordinated bi-national surveillance systems is crucial to achieve an efficient control of the SARS-CoV-2 spread across this kind of highly permeable borderland regions around the world. Frontiers Media S.A. 2021-05-28 /pmc/articles/PMC8195593/ /pubmed/34122369 http://dx.doi.org/10.3389/fmicb.2021.653986 Text en Copyright © 2021 Mir, Rego, Resende, Tort, Fernández-Calero, Noya, Brandes, Possi, Arleo, Reyes, Victoria, Lizasoain, Castells, Maya, Salvo, Schäffer Gregianini, Mar da Rosa, Garay Martins, Alonso, Vega, Salazar, Ferrés, Smircich, Sotelo Silveira, Fort, Mathó, Arantes, Appolinario, Mendonça, Benítez-Galeano, Simoes, Graña, Motta, Siqueira, Bello, Colina and Spangenberg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Mir, Daiana Rego, Natalia Resende, Paola Cristina Tort, Fernando Fernández-Calero, Tamara Noya, Verónica Brandes, Mariana Possi, Tania Arleo, Mailen Reyes, Natalia Victoria, Matías Lizasoain, Andres Castells, Matías Maya, Leticia Salvo, Matías Schäffer Gregianini, Tatiana Mar da Rosa, Marilda Tereza Garay Martins, Letícia Alonso, Cecilia Vega, Yasser Salazar, Cecilia Ferrés, Ignacio Smircich, Pablo Sotelo Silveira, Jose Fort, Rafael Sebastián Mathó, Cecilia Arantes, Ighor Appolinario, Luciana Mendonça, Ana Carolina Benítez-Galeano, María José Simoes, Camila Graña, Martín Motta, Fernando Siqueira, Marilda Mendonça Bello, Gonzalo Colina, Rodney Spangenberg, Lucía Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border |
title | Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border |
title_full | Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border |
title_fullStr | Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border |
title_full_unstemmed | Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border |
title_short | Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan–Brazilian Border |
title_sort | recurrent dissemination of sars-cov-2 through the uruguayan–brazilian border |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195593/ https://www.ncbi.nlm.nih.gov/pubmed/34122369 http://dx.doi.org/10.3389/fmicb.2021.653986 |
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