Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor (⍺(1)-AR) a...

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Detalles Bibliográficos
Autores principales: Koenecke, Allison, Powell, Michael, Xiong, Ruoxuan, Shen, Zhu, Fischer, Nicole, Huq, Sakibul, Khalafallah, Adham M, Trevisan, Marco, Sparen, Pär, Carrero, Juan J, Nishimura, Akihiko, Caffo, Brian, Stuart, Elizabeth A, Bai, Renyuan, Staedtke, Verena, Thomas, David L, Papadopoulos, Nickolas, Kinzler, Ken W, Vogelstein, Bert, Zhou, Shibin, Bettegowda, Chetan, Konig, Maximilian F, Mensh, Brett D, Vogelstein, Joshua T, Athey, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Epidemiology and Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195605/
https://www.ncbi.nlm.nih.gov/pubmed/34114951
http://dx.doi.org/10.7554/eLife.61700

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