Cargando…

Activation of Hippocampal IR/IRS-1 Signaling Contributes to the Treatment with Zuogui Jiangtang Jieyu Decoction on the Diabetes-Related Depression

BACKGROUND: Zuogui Jiangtang Jieyu decoction (ZJJ) is mainly used for the treatment of diabetes-related depression in current clinical applications and research. This study aims to investigate whether the brain IR/IRS-1 signaling pathway is involved in the therapeutic effect of ZJJ on depression-lik...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Hui, Ling, Jia, Meng, Pan, Liu, Jian, Lin, Xiaoyuan, Li, Wei, Wang, Yuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195672/ https://www.ncbi.nlm.nih.gov/pubmed/34149862 http://dx.doi.org/10.1155/2021/6688723

Ejemplares similares

Zuogui Jiangtang Jieyu Formulation Prevents Hyperglycaemia and Depressive-Like Behaviour in Rats by Reducing the Glucocorticoid Level in Plasma and Hippocampus
por: Wang, YuHong, et al.
Publicado: (2015)

Hypoglycemic and anti-depressant effects of Zuogui Jiangtang Jieyu formulation in a model of unpredictable chronic mild stress in rats with diabetes mellitus
por: WANG, YU-HONG, et al.
Publicado: (2014)

An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy
por: Huang, Yalan, et al.
Publicado: (2023)

Zuogui Jiangtang Shuxin formula Ameliorates diabetic cardiomyopathy mice via modulating gut-heart axis
por: Huang, Ya-lan, et al.
Publicado: (2023)

Therapeutic Targets and Mechanism of Xingpi Jieyu Decoction in Depression: A Network Pharmacology Study
por: Chang, Ze, et al.
Publicado: (2021)

Wenyang Jieyu Decoction Alleviates Depressive Behavior in the Rat Model of Depression via Regulation of the Intestinal Microbiota
por: Feng, Zhenyu, et al.
Publicado: (2020)

Efficacy and safety of Shugan Jieyu Decoction in the treatment of coronary heart disease complicated with depression
por: Li, Zhenzhen, et al.
Publicado: (2023)

Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity
por: Meng, Pan, et al.
Publicado: (2018)

Xingnao Jieyu Decoction Ameliorates Poststroke Depression through the BDNF/ERK/CREB Pathway in Rats
por: Li, Tao, et al.
Publicado: (2018)

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression
por: Wang, Dou, et al.
Publicado: (2021)

IRS1 Regulation by Wnt/β-Catenin Signaling and Varied Contribution of IRS1 to the Neoplastic Phenotype
por: Bommer, Guido T., et al.
Publicado: (2010)

Jiangtang Decoction Ameliorates Diabetic Kidney Disease Through the Modulation of the Gut Microbiota
por: Hong, Jinni, et al.
Publicado: (2023)

Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR(+/−)-IRS-1(+/−) Double Heterozygous (IR-IRS1dh) Mice
por: Franko, Andras, et al.
Publicado: (2017)

New isotopes 181Ir, 180Ir, 178Ir (Abstract)
por: Achmadjanov, A, et al.
Publicado: (1970)

Shugan Jieyu Capsule in Post-Stroke Depression Treatment: From Molecules to Systems
por: Zhang, Meng, et al.
Publicado: (2022)

Huoxue Jiangtang Decoction Alleviates Type 2 Diabetes Mellitus by Regulating the Oral Microbiota and Food Preferences
por: Huang, Qian, et al.
Publicado: (2022)

Meta-analysis of Shugan Jieyu Capsule for depression in patients with coronary heart disease
por: Liu, Zhen, et al.
Publicado: (2023)

Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
por: Fan, Wentao, et al.
Publicado: (2012)

Spectrometer operation in IR2 & IR8
por: Holzer, B J
Publicado: (2012)

New isotopes /sup 178/Ir, /sup 180/Ir, /sup 181/Ir
por: Akhmadzhanov, A I, et al.
Publicado: (1972)

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
por: Li, Heming, et al.
Publicado: (2017)

Near-IR & Mid-IR Silicon Photonics Modulators
por: Georgiev, Georgi V., et al.
Publicado: (2022)

Modulating paired Ir–O–Ir via electronic perturbations of correlated Ir single atoms to overcome catalytic selectivity
por: Chen, Shi-Hua, et al.
Publicado: (2023)

The Ir–OOOO–Ir transition state and the mechanism of the oxygen evolution reaction on IrO(2)(110)
por: Binninger, Tobias, et al.
Publicado: (2022)

IR Magnets
por: Todesco, Ezio
Publicado: (2011)

Structure-property relationships of photofunctional diiridium(II) complexes with tetracationic charge and an unsupported Ir–Ir bond
por: Zheng, Fangrui, et al.
Publicado: (2022)

Beam losses in the dispersion suppressors of IR3 and IR7
por: Baishev, I S, et al.
Publicado: (2001)

Optics constrains imposed by the injection in IR2 and IR8
por: Brüning, Oliver Sim, et al.
Publicado: (1998)

Ultrafast Continuum IR Generation and Its Application in IR Spectroscopy
por: Lim, Chaiho, et al.
Publicado: (2022)

The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine
por: Yan, Yongmei, et al.
Publicado: (2013)

Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression
por: Wang, Yuan, et al.
Publicado: (2020)

Machine-induced Background in the Near-beam Detectors IR1/IR5)Machine-induced Background in the Near-beam Detectors (IR1/IR5)
por: Azhgirey, I, et al.
Publicado: (2008)

Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin (Heart)-Pi (Spleen) Deficiency Syndrome: A Multi-centre Randomized Controlled Study
por: Chen, Xu, et al.
Publicado: (2022)

Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats
por: Du, Yuan, et al.
Publicado: (2020)

Erchen Decoction and Linguizhugan Decoction Ameliorate Hepatic Insulin Resistance by Inhibiting IRS-1Ser307 Phosphorylation In Vivo and In Vitro
por: Zhang, Huicun, et al.
Publicado: (2017)

Jianpi Jieyu Decoction, An Empirical Herbal Formula, Exerts Psychotropic Effects in Association With Modulation of Gut Microbial Diversity and GABA Activity
por: Liu, Lanying, et al.
Publicado: (2021)

IR1 and IR5 aperture at 3.5 TeV
por: Alabau Pons, C, et al.
Publicado: (2011)

Commissioning of the betatron squeeze to 1 m in IR1 and IR5
por: Assmann, R, et al.
Publicado: (2012)

Proton losses in the dispersion suppressors of IR1 and IR5 of LHC
por: Baishev, I S
Publicado: (2000)

Energy Deposition in the LHC Insertion Regions IR1 and IR5
por: Hoa, C, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_c0nqe8g4lrnc0201idopq1onha