Coagulation and wound repair during COVID-19

While COVID-19 is best known as a respiratory infection, SARS-CoV-2 causes systemic disease manifestations including coagulopathies. Both dysregulated extracellular matrix remodeling pathways and circulating coagulation proteins are hallmarks of severe COVID-19 and often continue after the resolutio...

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Detalles Bibliográficos
Autores principales: Menachery, Vineet D., Gralinski, Lisa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society for Heart and Lung Transplantation. 2021
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195688/
https://www.ncbi.nlm.nih.gov/pubmed/34334300
http://dx.doi.org/10.1016/j.healun.2021.06.006
Descripción
Sumario:While COVID-19 is best known as a respiratory infection, SARS-CoV-2 causes systemic disease manifestations including coagulopathies. Both dysregulated extracellular matrix remodeling pathways and circulating coagulation proteins are hallmarks of severe COVID-19 and often continue after the resolution of acute infection. Coagulation proteins have proven effective as biomarkers for severe disease and anticoagulants are a mainstay of COVID-19 therapeutics in hospitalized patients. While much knowledge has been gained about the role of clotting pathway activation in COVID-19, much remains to be elucidated in this complex network of signaling pathways.

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