Synthetic biology approaches to actinomycete strain improvement

Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synt...

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Detalles Bibliográficos
Autores principales: Breitling, Rainer, Avbelj, Martina, Bilyk, Oksana, Carratore, Francesco Del, Filisetti, Alessandro, Hanko, Erik K R, Iorio, Marianna, Redondo, Rosario Pérez, Reyes, Fernando, Rudden, Michelle, Severi, Emmanuele, Slemc, Lucija, Schmidt, Kamila, Whittall, Dominic R, Donadio, Stefano, García, Antonio Rodríguez, Genilloud, Olga, Kosec, Gregor, De Lucrezia, Davide, Petković, Hrvoje, Thomas, Gavin, Takano, Eriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195692/
https://www.ncbi.nlm.nih.gov/pubmed/34057181
http://dx.doi.org/10.1093/femsle/fnab060
Descripción
Sumario:Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

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