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The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study

BACKGROUND: Whether the carriership of inherited antithrombin (AT), protein C (PC), and protein S (PS) deficiency increases the risk of arterial thromboembolic events (ATE) is controversial. This information has the potential to inform the management of family members of probands with inherited defi...

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Autores principales: Tormene, Daniela, Noventa, Franco, Campello, Elena, Gavasso, Sabrina, Marobin, Michelangelo, Turatti, Giacomo, Prandoni, Paolo, Simioni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195788/
https://www.ncbi.nlm.nih.gov/pubmed/33619677
http://dx.doi.org/10.1007/s11739-021-02656-5
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author Tormene, Daniela
Noventa, Franco
Campello, Elena
Gavasso, Sabrina
Marobin, Michelangelo
Turatti, Giacomo
Prandoni, Paolo
Simioni, Paolo
author_facet Tormene, Daniela
Noventa, Franco
Campello, Elena
Gavasso, Sabrina
Marobin, Michelangelo
Turatti, Giacomo
Prandoni, Paolo
Simioni, Paolo
author_sort Tormene, Daniela
collection PubMed
description BACKGROUND: Whether the carriership of inherited antithrombin (AT), protein C (PC), and protein S (PS) deficiency increases the risk of arterial thromboembolic events (ATE) is controversial. This information has the potential to inform the management of family members of probands with inherited deficiency of natural anticoagulants. PATIENTS/METHODS: We conducted a large prospective family cohort study in 640 subjects (of whom 341 carriers and 299 non-carriers) belonging to 86 families with inherited deficiency of AT, PC, or PS. RESULTS: A total of 4240 and 3810 patient-years were available for carriers and non-carriers, respectively. Risk factors for atherosclerosis were similarly distributed in the two groups. Of the 26 ATE that were recorded, 19 occurred in carriers (5.6%), as compared to 7 in non-carriers (2.3%) [p = 0.07]. After adjusting for confounders, the hazard ratio (HR) for ATE was 4.9 (95% CI 1.5–16.3) in carriers as compared to non-carriers. CONCLUSIONS: Among family members of probands with an inherited deficiency of natural anticoagulants, carriers exhibit a risk of ATE that is almost five times higher than in non-carriers.
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spelling pubmed-81957882021-06-28 The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study Tormene, Daniela Noventa, Franco Campello, Elena Gavasso, Sabrina Marobin, Michelangelo Turatti, Giacomo Prandoni, Paolo Simioni, Paolo Intern Emerg Med Im - Original BACKGROUND: Whether the carriership of inherited antithrombin (AT), protein C (PC), and protein S (PS) deficiency increases the risk of arterial thromboembolic events (ATE) is controversial. This information has the potential to inform the management of family members of probands with inherited deficiency of natural anticoagulants. PATIENTS/METHODS: We conducted a large prospective family cohort study in 640 subjects (of whom 341 carriers and 299 non-carriers) belonging to 86 families with inherited deficiency of AT, PC, or PS. RESULTS: A total of 4240 and 3810 patient-years were available for carriers and non-carriers, respectively. Risk factors for atherosclerosis were similarly distributed in the two groups. Of the 26 ATE that were recorded, 19 occurred in carriers (5.6%), as compared to 7 in non-carriers (2.3%) [p = 0.07]. After adjusting for confounders, the hazard ratio (HR) for ATE was 4.9 (95% CI 1.5–16.3) in carriers as compared to non-carriers. CONCLUSIONS: Among family members of probands with an inherited deficiency of natural anticoagulants, carriers exhibit a risk of ATE that is almost five times higher than in non-carriers. Springer International Publishing 2021-02-22 2021 /pmc/articles/PMC8195788/ /pubmed/33619677 http://dx.doi.org/10.1007/s11739-021-02656-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Im - Original
Tormene, Daniela
Noventa, Franco
Campello, Elena
Gavasso, Sabrina
Marobin, Michelangelo
Turatti, Giacomo
Prandoni, Paolo
Simioni, Paolo
The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study
title The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study
title_full The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study
title_fullStr The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study
title_full_unstemmed The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study
title_short The risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study
title_sort risk of arterial thrombosis in carriers of natural coagulation inhibitors: a prospective family cohort study
topic Im - Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195788/
https://www.ncbi.nlm.nih.gov/pubmed/33619677
http://dx.doi.org/10.1007/s11739-021-02656-5
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