CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma

INTRODUCTION: CD73 is a membrane-bound enzyme crucial in adenosine generation. The adenosinergic pathway plays a critical role in immunosuppression and in anti-tumor effects of immune checkpoint inhibitors (ICI). Here, we interrogated CD73 expression in a richly annotated cohort of human lung adenoc...

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Detalles Bibliográficos
Autores principales: Rocha, Pedro, Salazar, Ruth, Zhang, Jiexin, Ledesma, Debora, Solorzano, Jose L., Mino, Barbara, Villalobos, Pamela, Dejima, Hitoshi, Douse, Dzifa Y., Diao, Lixia, Mitchell, Kyle Gregory, Le, Xiuning, Zhang, Jianjun, Weissferdt, Annikka, Parra-Cuentas, Edwin, Cascone, Tina, Rice, David C., Sepesi, Boris, Kalhor, Neda, Moran, Cesar, Vaporciyan, Ara, Heymach, John, Gibbons, Don L., Lee, J. Jack, Kadara, Humam, Wistuba, Ignacio, Behrens, Carmen, Solis, Luisa Maren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195808/
https://www.ncbi.nlm.nih.gov/pubmed/33416944
http://dx.doi.org/10.1007/s00262-020-02820-4

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