Engineering of the unfolded protein response pathway in Pichia pastoris: enhancing production of secreted recombinant proteins

ABSTRACT: Folding and processing of proteins in the endoplasmic reticulum (ER) are major impediments in the production and secretion of proteins from Pichia pastoris (Komagataella sp.). Overexpression of recombinant genes can overwhelm the innate secretory machinery of the P. pastoris cell, and inco...

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Detalles Bibliográficos
Autores principales: Raschmanová, Hana, Weninger, Astrid, Knejzlík, Zdeněk, Melzoch, Karel, Kovar, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195892/
https://www.ncbi.nlm.nih.gov/pubmed/34037840
http://dx.doi.org/10.1007/s00253-021-11336-5

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