Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a mode...

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Detalles Bibliográficos
Autores principales: Zhou, Yueying, Xin, Xiaonan, Wang, Lichao, Wang, Binsheng, Chen, Li, Liu, Ousheng, Rowe, David W., Xu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195980/
https://www.ncbi.nlm.nih.gov/pubmed/34117259
http://dx.doi.org/10.1038/s41536-021-00145-z
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author Zhou, Yueying
Xin, Xiaonan
Wang, Lichao
Wang, Binsheng
Chen, Li
Liu, Ousheng
Rowe, David W.
Xu, Ming
author_facet Zhou, Yueying
Xin, Xiaonan
Wang, Lichao
Wang, Binsheng
Chen, Li
Liu, Ousheng
Rowe, David W.
Xu, Ming
author_sort Zhou, Yueying
collection PubMed
description The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.
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spelling pubmed-81959802021-06-17 Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice Zhou, Yueying Xin, Xiaonan Wang, Lichao Wang, Binsheng Chen, Li Liu, Ousheng Rowe, David W. Xu, Ming NPJ Regen Med Brief Communication The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations. Nature Publishing Group UK 2021-06-11 /pmc/articles/PMC8195980/ /pubmed/34117259 http://dx.doi.org/10.1038/s41536-021-00145-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Zhou, Yueying
Xin, Xiaonan
Wang, Lichao
Wang, Binsheng
Chen, Li
Liu, Ousheng
Rowe, David W.
Xu, Ming
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_full Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_fullStr Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_full_unstemmed Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_short Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
title_sort senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195980/
https://www.ncbi.nlm.nih.gov/pubmed/34117259
http://dx.doi.org/10.1038/s41536-021-00145-z
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