Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a mode...

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Detalles Bibliográficos
Autores principales: Zhou, Yueying, Xin, Xiaonan, Wang, Lichao, Wang, Binsheng, Chen, Li, Liu, Ousheng, Rowe, David W., Xu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195980/
https://www.ncbi.nlm.nih.gov/pubmed/34117259
http://dx.doi.org/10.1038/s41536-021-00145-z

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