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Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI

Functional magnetic resonance imaging (fMRI) has significant potential to evaluate changes in brain network activity after traumatic brain injury (TBI) and enable early prognosis of potential functional (e.g., motor, cognitive, behavior) deficits. In this study, resting-state and task-based fMRI (rs...

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Autores principales: Simchick, Gregory, Scheulin, Kelly M., Sun, Wenwu, Sneed, Sydney E., Fagan, Madison M., Cheek, Savannah R., West, Franklin D., Zhao, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196021/
https://www.ncbi.nlm.nih.gov/pubmed/34117318
http://dx.doi.org/10.1038/s41598-021-91853-5
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author Simchick, Gregory
Scheulin, Kelly M.
Sun, Wenwu
Sneed, Sydney E.
Fagan, Madison M.
Cheek, Savannah R.
West, Franklin D.
Zhao, Qun
author_facet Simchick, Gregory
Scheulin, Kelly M.
Sun, Wenwu
Sneed, Sydney E.
Fagan, Madison M.
Cheek, Savannah R.
West, Franklin D.
Zhao, Qun
author_sort Simchick, Gregory
collection PubMed
description Functional magnetic resonance imaging (fMRI) has significant potential to evaluate changes in brain network activity after traumatic brain injury (TBI) and enable early prognosis of potential functional (e.g., motor, cognitive, behavior) deficits. In this study, resting-state and task-based fMRI (rs- and tb-fMRI) were utilized to examine network changes in a pediatric porcine TBI model that has increased predictive potential in the development of novel therapies. rs- and tb-fMRI were performed one day post-TBI in piglets. Activation maps were generated using group independent component analysis (ICA) and sparse dictionary learning (sDL). Activation maps were compared to pig reference functional connectivity atlases and evaluated using Pearson spatial correlation coefficients and mean ratios. Nonparametric permutation analyses were used to determine significantly different activation areas between the TBI and healthy control groups. Significantly lower Pearson values and mean ratios were observed in the visual, executive control, and sensorimotor networks for TBI piglets compared to controls. Significant differences were also observed within several specific individual anatomical structures within each network. In conclusion, both rs- and tb-fMRI demonstrate the ability to detect functional connectivity disruptions in a translational TBI piglet model, and these disruptions can be traced to specific affected anatomical structures.
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spelling pubmed-81960212021-06-15 Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI Simchick, Gregory Scheulin, Kelly M. Sun, Wenwu Sneed, Sydney E. Fagan, Madison M. Cheek, Savannah R. West, Franklin D. Zhao, Qun Sci Rep Article Functional magnetic resonance imaging (fMRI) has significant potential to evaluate changes in brain network activity after traumatic brain injury (TBI) and enable early prognosis of potential functional (e.g., motor, cognitive, behavior) deficits. In this study, resting-state and task-based fMRI (rs- and tb-fMRI) were utilized to examine network changes in a pediatric porcine TBI model that has increased predictive potential in the development of novel therapies. rs- and tb-fMRI were performed one day post-TBI in piglets. Activation maps were generated using group independent component analysis (ICA) and sparse dictionary learning (sDL). Activation maps were compared to pig reference functional connectivity atlases and evaluated using Pearson spatial correlation coefficients and mean ratios. Nonparametric permutation analyses were used to determine significantly different activation areas between the TBI and healthy control groups. Significantly lower Pearson values and mean ratios were observed in the visual, executive control, and sensorimotor networks for TBI piglets compared to controls. Significant differences were also observed within several specific individual anatomical structures within each network. In conclusion, both rs- and tb-fMRI demonstrate the ability to detect functional connectivity disruptions in a translational TBI piglet model, and these disruptions can be traced to specific affected anatomical structures. Nature Publishing Group UK 2021-06-11 /pmc/articles/PMC8196021/ /pubmed/34117318 http://dx.doi.org/10.1038/s41598-021-91853-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Simchick, Gregory
Scheulin, Kelly M.
Sun, Wenwu
Sneed, Sydney E.
Fagan, Madison M.
Cheek, Savannah R.
West, Franklin D.
Zhao, Qun
Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI
title Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI
title_full Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI
title_fullStr Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI
title_full_unstemmed Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI
title_short Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI
title_sort detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fmri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196021/
https://www.ncbi.nlm.nih.gov/pubmed/34117318
http://dx.doi.org/10.1038/s41598-021-91853-5
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