K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR

Dual specificity tyrosine phosphorylation regulated kinase 1A, DYRK1A, functions in multiple cellular pathways, including signaling, endocytosis, synaptic transmission, and transcription. Alterations in dosage of DYRK1A leads to defects in neurogenesis, cell growth, and differentiation, and may incr...

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Detalles Bibliográficos
Autores principales: Zhang, Pengshan, Zhang, Zhe, Fu, Yinkun, Zhang, Ying, Washburn, Michael P., Florens, Laurence, Wu, Min, Huang, Chen, Hou, Zhaoyuan, Mohan, Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196033/
https://www.ncbi.nlm.nih.gov/pubmed/34117217
http://dx.doi.org/10.1038/s41419-021-03887-2

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