A novel fusion protein TBLR1-RARα acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies

Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation involving RARα and its fusion partners. For decades, the advent of all-trans retinoic acid (ATRA) synergized with arsenic trioxide (As(2)O(3)) has turned most APL from highly fatal to highly curable. TBLR1-RAR...

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Detalles Bibliográficos
Autores principales: Li, Shouyun, Yang, Xue, Liu, Shuang, Chen, Yirui, Xing, Haiyan, Tang, Kejing, Tian, Zheng, Xu, Yingxi, Rao, Qing, Wang, Min, Wang, Jianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196070/
https://www.ncbi.nlm.nih.gov/pubmed/34117212
http://dx.doi.org/10.1038/s41419-021-03889-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196070/
https://www.ncbi.nlm.nih.gov/pubmed/34117212
http://dx.doi.org/10.1038/s41419-021-03889-0

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