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Overexpression of human BAG3(P209L) in mice causes restrictive cardiomyopathy

An amino acid exchange (P209L) in the HSPB8 binding site of the human co-chaperone BAG3 gives rise to severe childhood cardiomyopathy. To phenocopy the disease in mice and gain insight into its mechanisms, we generated humanized transgenic mouse models. Expression of human BAG3(P209L)-eGFP in mice c...

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Detalles Bibliográficos
Autores principales:	Kimura, Kenichi, Ooms, Astrid, Graf-Riesen, Kathrin, Kuppusamy, Maithreyan, Unger, Andreas, Schuld, Julia, Daerr, Jan, Lother, Achim, Geisen, Caroline, Hein, Lutz, Takahashi, Satoru, Li, Guang, Röll, Wilhelm, Bloch, Wilhelm, van der Ven, Peter F. M., Linke, Wolfgang A., Wu, Sean M., Huesgen, Pitter F., Höhfeld, Jörg, Fürst, Dieter O., Fleischmann, Bernd K., Hesse, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196106/ https://www.ncbi.nlm.nih.gov/pubmed/34117258 http://dx.doi.org/10.1038/s41467-021-23858-7

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