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Plasma methionine metabolic profile is associated with longevity in mammals

Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative approach to analyse plasma methionine metabolic profile using a LC-MS/MS p...

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Autores principales: Mota-Martorell, N., Jové, M., Berdún, R., Pamplona, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196171/
https://www.ncbi.nlm.nih.gov/pubmed/34117367
http://dx.doi.org/10.1038/s42003-021-02254-3
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author Mota-Martorell, N.
Jové, M.
Berdún, R.
Pamplona, R.
author_facet Mota-Martorell, N.
Jové, M.
Berdún, R.
Pamplona, R.
author_sort Mota-Martorell, N.
collection PubMed
description Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative approach to analyse plasma methionine metabolic profile using a LC-MS/MS platform from 11 mammalian species with a longevity ranging from 3.5 to 120 years. Our findings demonstrate the existence of a species-specific plasma profile for methionine metabolism associated with longevity characterised by: i) reduced methionine, cystathionine and choline; ii) increased non-polar amino acids; iii) reduced succinate and malate; and iv) increased carnitine. Our results support the existence of plasma longevity features that might respond to an optimised energetic metabolism and intracellular structures found in long-lived species.
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spelling pubmed-81961712021-06-17 Plasma methionine metabolic profile is associated with longevity in mammals Mota-Martorell, N. Jové, M. Berdún, R. Pamplona, R. Commun Biol Article Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative approach to analyse plasma methionine metabolic profile using a LC-MS/MS platform from 11 mammalian species with a longevity ranging from 3.5 to 120 years. Our findings demonstrate the existence of a species-specific plasma profile for methionine metabolism associated with longevity characterised by: i) reduced methionine, cystathionine and choline; ii) increased non-polar amino acids; iii) reduced succinate and malate; and iv) increased carnitine. Our results support the existence of plasma longevity features that might respond to an optimised energetic metabolism and intracellular structures found in long-lived species. Nature Publishing Group UK 2021-06-11 /pmc/articles/PMC8196171/ /pubmed/34117367 http://dx.doi.org/10.1038/s42003-021-02254-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mota-Martorell, N.
Jové, M.
Berdún, R.
Pamplona, R.
Plasma methionine metabolic profile is associated with longevity in mammals
title Plasma methionine metabolic profile is associated with longevity in mammals
title_full Plasma methionine metabolic profile is associated with longevity in mammals
title_fullStr Plasma methionine metabolic profile is associated with longevity in mammals
title_full_unstemmed Plasma methionine metabolic profile is associated with longevity in mammals
title_short Plasma methionine metabolic profile is associated with longevity in mammals
title_sort plasma methionine metabolic profile is associated with longevity in mammals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196171/
https://www.ncbi.nlm.nih.gov/pubmed/34117367
http://dx.doi.org/10.1038/s42003-021-02254-3
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