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Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation

Deletion of c-Src, a ubiquitously expressed tyrosine kinase, results in osteoclast dysfunction and osteopetrosis, in which bones harden into “stone.” In contrast, deletion of the genes encoding other members of the Src family kinase (SFK) fails to produce an osteopetrotic phenotype. This suggests th...

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Detalles Bibliográficos
Autores principales:	Matsubara, Takuma, Addison, William N., Kokabu, Shoichiro, Neff, Lynn, Horne, William, Gori, Francesca, Baron, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196221/ https://www.ncbi.nlm.nih.gov/pubmed/34019873 http://dx.doi.org/10.1016/j.jbc.2021.100790

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