Cargando…

Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog

BACKGROUND: Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate to ubiquinone in the mitochondrial electron transport chain (ETC). Mutations in Complex II...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bandara, Aloka B., Drake, Joshua C., Brown, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196461/ https://www.ncbi.nlm.nih.gov/pubmed/34118887 http://dx.doi.org/10.1186/s12860-021-00370-w

Ejemplares similares

Sdhd and Sdhd/H19 Knockout Mice Do Not Develop Paraganglioma or Pheochromocytoma
por: Bayley, Jean-Pierre, et al.
Publicado: (2009)

No evidence for involvement of SDHD in neuroblastoma pathogenesis
por: De Preter, Katleen, et al.
Publicado: (2004)

SDHD promoter mutations are rare events in cutaneous melanomas but SDHD protein expression is downregulated in advanced cutaneous melanoma
por: Pópulo, Helena, et al.
Publicado: (2017)

Clinical picture: SDHD paraganglioma presenting with syncope
por: LaChance, David P., et al.
Publicado: (2020)

The Subunit Composition of Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) From Pichia pastoris
por: Bridges, Hannah R., et al.
Publicado: (2010)

Ubiquinone Analogs: A Mitochondrial Permeability Transition Pore-Dependent Pathway to Selective Cell Death
por: Devun, Flavien, et al.
Publicado: (2010)

Tumour risks and genotype–phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD
por: Andrews, Katrina A, et al.
Publicado: (2018)

Analysis of SDHD promoter mutations in various types of melanoma
por: Scholz, Simone L., et al.
Publicado: (2015)

Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations
por: Bayley, Jean-Pierre, et al.
Publicado: (2014)

Germline SDHB and SDHD mutations in pheochromocytoma and paraganglioma patients
por: Huang, Yiqiang, et al.
Publicado: (2018)

Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers
por: Rijken, Johannes A., et al.
Publicado: (2019)

Correction: Tumour risks and genotype-phenotype correlations associated with germline variants in the succinate dehydrogenase subunit genes SDHB, SDHC, and SDHD
Publicado: (2019)

Role of Subunit D in Ubiquinone-Binding Site of Vibrio cholerae NQR: Pocket Flexibility and Inhibitor Resistance
por: Raba, Daniel A., et al.
Publicado: (2019)

RegB Kinase Activity Is Controlled in Part by Monitoring the Ratio of Oxidized to Reduced Ubiquinones in the Ubiquinone Pool
por: Wu, Jiang, et al.
Publicado: (2010)

Reduction of Hydrophilic Ubiquinones by the Flavin in Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) and Production of Reactive Oxygen Species
por: King, Martin S., et al.
Publicado: (2009)

Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit
por: Tomitsuka, Eriko, et al.
Publicado: (2009)

Treatment of CoQ(10) Deficient Fibroblasts with Ubiquinone, CoQ Analogs, and Vitamin C: Time- and Compound-Dependent Effects
por: López, Luis C., et al.
Publicado: (2010)

Computational Identification and Analysis of Ubiquinone-Binding Proteins
por: Lu, Chang, et al.
Publicado: (2020)

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
por: Bejarano-García, José Antonio, et al.
Publicado: (2016)

Consolidating biallelic SDHD variants as a cause of mitochondrial complex II deficiency
por: Lin, Siying, et al.
Publicado: (2021)

Tumour detection and outcomes of surveillance screening in SDHB and SDHD pathogenic variant carriers
por: White, Gemma, et al.
Publicado: (2022)

Pheochromocytoma due to a novel SDHD variant presenting as unilateral visual loss
por: Miller, Clare, et al.
Publicado: (2021)

In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit
por: Raffa, Salvatore, et al.
Publicado: (2017)

Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells
por: Yu, Wanfeng, et al.
Publicado: (2017)

Quantifying evidence toward pathogenicity for rare phenotypes: The case of succinate dehydrogenase genes, SDHB and SDHD
por: Garrett, Alice, et al.
Publicado: (2022)

Nonspecific resistance to bacterial infections. Enhancement by ubiquinone-8
Publicado: (1978)

Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival
por: Hekimi, Siegfried, et al.
Publicado: (2011)

Origin and Evolution of the Sodium -Pumping NADH: Ubiquinone Oxidoreductase
por: Reyes-Prieto, Adrian, et al.
Publicado: (2014)

Molecular Mechanisms Associated with the Induction of Ubiquinone by Peroxisome Proliferators
por: Khan, Seher Akhtar
Publicado: (2009)

Incomplete penetrance of a novel SDHD variation causing familial head and neck paraganglioma
por: Koenighofer, Martin, et al.
Publicado: (2021)

Clinical Relevance and Tumor Growth Suppression of Mitochondrial ROS Regulators along NADH:Ubiquinone Oxidoreductase Subunit B3 in Thyroid Cancer
por: Zhu, Jiao, et al.
Publicado: (2022)

Analog synthetic biology
por: Sarpeshkar, R.
Publicado: (2014)

Commentary: Synthetic Ubiquinones Specifically Bind to Mitochondrial Voltage-Dependent Anion Channel 1 (VDAC1) in Saccharomyces cerevisiae Mitochondria
por: Gutiérrez-Aguilar, Manuel
Publicado: (2017)

Over-representation of the G12S polymorphism of the SDHD gene in patients with MEN2A syndrome
por: Lendvai, Nikoletta, et al.
Publicado: (2012)

Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma/paraganglioma patients
por: Bennedbæk, Marc, et al.
Publicado: (2016)

Pheochromocytoma, paragangliomas, and pituitary adenoma: An unusual association in a patient with an SDHD mutation. Case report
por: Lemelin, Annie, et al.
Publicado: (2019)

MON-249 SDHD Mutation: Nonfunctional Paragangliomas Presenting as Bilateral Carotid Body Tumors with Syncope
por: LaChance, David, et al.
Publicado: (2020)

An aggressive and expanded phenotype in a kindred with a c.57delG SDHD mutation
por: Caetano, Celina, et al.
Publicado: (2021)

Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas
por: Bayley, Jean-Pierre, et al.
Publicado: (2022)

FRI368 Thyroid Paraganglioma: A Rare Manifestation Of Paraganglioma Syndrome Associated With SDHD Mutation
por: Samuel, Kelara, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gfmbg7r64cv1njckfqngsg26h9