Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts

Background/Purpose: The rates and outcomes of primary biliary cholangitis (PBC) in Taiwan remain unclear. Methods: A nationwide population-based cohort study (Taiwan National Health Insurance Research Database, 2002–2015) was conducted. Data from four PBC cohorts with various definitions were compar...

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Autores principales: Chen, Cheng-Jen, Cheng, Jur-Shan, Wang, Haw-En, Huang, Chun-Wen, Hu, Jing-Hong, Chen, Wei-Ting, Chang, Ming-Yu, Ku, Hsin-Ping, Lin, Cheng-Yu, Chien, Rong-Nan, Chang, Ming-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196594/
https://www.ncbi.nlm.nih.gov/pubmed/34063859
http://dx.doi.org/10.3390/jcm10112226
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author Chen, Cheng-Jen
Cheng, Jur-Shan
Wang, Haw-En
Huang, Chun-Wen
Hu, Jing-Hong
Chen, Wei-Ting
Chang, Ming-Yu
Ku, Hsin-Ping
Lin, Cheng-Yu
Chien, Rong-Nan
Chang, Ming-Ling
author_facet Chen, Cheng-Jen
Cheng, Jur-Shan
Wang, Haw-En
Huang, Chun-Wen
Hu, Jing-Hong
Chen, Wei-Ting
Chang, Ming-Yu
Ku, Hsin-Ping
Lin, Cheng-Yu
Chien, Rong-Nan
Chang, Ming-Ling
author_sort Chen, Cheng-Jen
collection PubMed
description Background/Purpose: The rates and outcomes of primary biliary cholangitis (PBC) in Taiwan remain unclear. Methods: A nationwide population-based cohort study (Taiwan National Health Insurance Research Database, 2002–2015) was conducted. Data from four PBC cohorts with various definitions were compared (cohort 1 (C1): ICD-9-CM (571.6); C2: alkaline phosphatase (Alk-P) and antimitochondrial antibody (AMA) measurements; C3: Alk-p and AMA measurements and ursodeoxycholic acid (UDCA) treatment; C4: ICD-9-CM (571.6), Alk-p and AMA measurements and UDCA treatment). Results: The average prevalence rate ranged from 9.419/10(5) (C4) to 307.658/10(5) (C2), and the female-to-male ratio ranged from 1.192 (C1) to 3.66 (C4). Prevalence rates increased over time in all cohorts. The average incidence rates ranged from 1.456/10(5) (C4) to 66.386/10(5) (C2). Incidence rates decreased over time in C1 (−9.09%, p < 0.0001) and C4 (−6.68%, p < 0.0001) and remained steady in the others. C4 had the lowest prevalence and incidence rates and highest female-to-male ratio. Cirrhosis rates ranged from 7.21% (C2) to 39.34% (C4), hepatoma rates ranged from 2.77%(C2) to 6.66%(C1), liver transplantation (LT) rates ranged from 1.07% (C2) to 6.77% (C4), and mortality rates ranged from 18.24% (C2) to 47.36% (C1). C4 had the highest LT (6.77%), osteoporosis (13.87%) and dyslipidemia rates (17.21%). Conclusions: Based on the reported ranges of reasonable rates, female predominance and characteristic outcomes, C4 was the most representative Taiwanese PBC cohort, with average prevalence and incidence rates of 9.419/10(5) and 1.456/10(5), respectively, and a female-to-male ratio of 3.66. In a 14-year period, cirrhosis, hepatoma, LT, and mortality were noted in 39.34%, 5.52%, 6.77%, and 34.22% of C4 patients, respectively.
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spelling pubmed-81965942021-06-13 Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts Chen, Cheng-Jen Cheng, Jur-Shan Wang, Haw-En Huang, Chun-Wen Hu, Jing-Hong Chen, Wei-Ting Chang, Ming-Yu Ku, Hsin-Ping Lin, Cheng-Yu Chien, Rong-Nan Chang, Ming-Ling J Clin Med Article Background/Purpose: The rates and outcomes of primary biliary cholangitis (PBC) in Taiwan remain unclear. Methods: A nationwide population-based cohort study (Taiwan National Health Insurance Research Database, 2002–2015) was conducted. Data from four PBC cohorts with various definitions were compared (cohort 1 (C1): ICD-9-CM (571.6); C2: alkaline phosphatase (Alk-P) and antimitochondrial antibody (AMA) measurements; C3: Alk-p and AMA measurements and ursodeoxycholic acid (UDCA) treatment; C4: ICD-9-CM (571.6), Alk-p and AMA measurements and UDCA treatment). Results: The average prevalence rate ranged from 9.419/10(5) (C4) to 307.658/10(5) (C2), and the female-to-male ratio ranged from 1.192 (C1) to 3.66 (C4). Prevalence rates increased over time in all cohorts. The average incidence rates ranged from 1.456/10(5) (C4) to 66.386/10(5) (C2). Incidence rates decreased over time in C1 (−9.09%, p < 0.0001) and C4 (−6.68%, p < 0.0001) and remained steady in the others. C4 had the lowest prevalence and incidence rates and highest female-to-male ratio. Cirrhosis rates ranged from 7.21% (C2) to 39.34% (C4), hepatoma rates ranged from 2.77%(C2) to 6.66%(C1), liver transplantation (LT) rates ranged from 1.07% (C2) to 6.77% (C4), and mortality rates ranged from 18.24% (C2) to 47.36% (C1). C4 had the highest LT (6.77%), osteoporosis (13.87%) and dyslipidemia rates (17.21%). Conclusions: Based on the reported ranges of reasonable rates, female predominance and characteristic outcomes, C4 was the most representative Taiwanese PBC cohort, with average prevalence and incidence rates of 9.419/10(5) and 1.456/10(5), respectively, and a female-to-male ratio of 3.66. In a 14-year period, cirrhosis, hepatoma, LT, and mortality were noted in 39.34%, 5.52%, 6.77%, and 34.22% of C4 patients, respectively. MDPI 2021-05-21 /pmc/articles/PMC8196594/ /pubmed/34063859 http://dx.doi.org/10.3390/jcm10112226 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Cheng-Jen
Cheng, Jur-Shan
Wang, Haw-En
Huang, Chun-Wen
Hu, Jing-Hong
Chen, Wei-Ting
Chang, Ming-Yu
Ku, Hsin-Ping
Lin, Cheng-Yu
Chien, Rong-Nan
Chang, Ming-Ling
Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts
title Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts
title_full Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts
title_fullStr Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts
title_full_unstemmed Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts
title_short Identification of the Representative Primary Biliary Cholangitis Cohort in Taiwan: A Comparison of Four Nationwide Cohorts
title_sort identification of the representative primary biliary cholangitis cohort in taiwan: a comparison of four nationwide cohorts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196594/
https://www.ncbi.nlm.nih.gov/pubmed/34063859
http://dx.doi.org/10.3390/jcm10112226
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