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Antimicrobial Polymer−Based Assemblies: A Review
An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196616/ https://www.ncbi.nlm.nih.gov/pubmed/34063877 http://dx.doi.org/10.3390/ijms22115424 |
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author | Carmona-Ribeiro, Ana Maria Araújo, Péricles Marques |
author_facet | Carmona-Ribeiro, Ana Maria Araújo, Péricles Marques |
author_sort | Carmona-Ribeiro, Ana Maria |
collection | PubMed |
description | An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs. |
format | Online Article Text |
id | pubmed-8196616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81966162021-06-13 Antimicrobial Polymer−Based Assemblies: A Review Carmona-Ribeiro, Ana Maria Araújo, Péricles Marques Int J Mol Sci Review An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs. MDPI 2021-05-21 /pmc/articles/PMC8196616/ /pubmed/34063877 http://dx.doi.org/10.3390/ijms22115424 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carmona-Ribeiro, Ana Maria Araújo, Péricles Marques Antimicrobial Polymer−Based Assemblies: A Review |
title | Antimicrobial Polymer−Based Assemblies: A Review |
title_full | Antimicrobial Polymer−Based Assemblies: A Review |
title_fullStr | Antimicrobial Polymer−Based Assemblies: A Review |
title_full_unstemmed | Antimicrobial Polymer−Based Assemblies: A Review |
title_short | Antimicrobial Polymer−Based Assemblies: A Review |
title_sort | antimicrobial polymer−based assemblies: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196616/ https://www.ncbi.nlm.nih.gov/pubmed/34063877 http://dx.doi.org/10.3390/ijms22115424 |
work_keys_str_mv | AT carmonaribeiroanamaria antimicrobialpolymerbasedassembliesareview AT araujopericlesmarques antimicrobialpolymerbasedassembliesareview |