Cargando…

Antimicrobial Polymer−Based Assemblies: A Review

An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and a...

Descripción completa

Detalles Bibliográficos
Autores principales: Carmona-Ribeiro, Ana Maria, Araújo, Péricles Marques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196616/
https://www.ncbi.nlm.nih.gov/pubmed/34063877
http://dx.doi.org/10.3390/ijms22115424
_version_ 1783706727342931968
author Carmona-Ribeiro, Ana Maria
Araújo, Péricles Marques
author_facet Carmona-Ribeiro, Ana Maria
Araújo, Péricles Marques
author_sort Carmona-Ribeiro, Ana Maria
collection PubMed
description An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs.
format Online
Article
Text
id pubmed-8196616
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81966162021-06-13 Antimicrobial Polymer−Based Assemblies: A Review Carmona-Ribeiro, Ana Maria Araújo, Péricles Marques Int J Mol Sci Review An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs. MDPI 2021-05-21 /pmc/articles/PMC8196616/ /pubmed/34063877 http://dx.doi.org/10.3390/ijms22115424 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carmona-Ribeiro, Ana Maria
Araújo, Péricles Marques
Antimicrobial Polymer−Based Assemblies: A Review
title Antimicrobial Polymer−Based Assemblies: A Review
title_full Antimicrobial Polymer−Based Assemblies: A Review
title_fullStr Antimicrobial Polymer−Based Assemblies: A Review
title_full_unstemmed Antimicrobial Polymer−Based Assemblies: A Review
title_short Antimicrobial Polymer−Based Assemblies: A Review
title_sort antimicrobial polymer−based assemblies: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196616/
https://www.ncbi.nlm.nih.gov/pubmed/34063877
http://dx.doi.org/10.3390/ijms22115424
work_keys_str_mv AT carmonaribeiroanamaria antimicrobialpolymerbasedassembliesareview
AT araujopericlesmarques antimicrobialpolymerbasedassembliesareview