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White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients

Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-...

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Autores principales: Podwalski, Piotr, Tyburski, Ernest, Szczygieł, Krzysztof, Waszczuk, Katarzyna, Rek-Owodziń, Katarzyna, Mak, Monika, Plichta, Piotr, Bielecki, Maksymilian, Rudkowski, Krzysztof, Kucharska-Mazur, Jolanta, Andrusewicz, Wojciech, Misiak, Błażej, Szulc, Agata, Michalczyk, Anna, Michałowska, Sylwia, Sagan, Leszek, Samochowiec, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196621/
https://www.ncbi.nlm.nih.gov/pubmed/34063845
http://dx.doi.org/10.3390/jcm10112225
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author Podwalski, Piotr
Tyburski, Ernest
Szczygieł, Krzysztof
Waszczuk, Katarzyna
Rek-Owodziń, Katarzyna
Mak, Monika
Plichta, Piotr
Bielecki, Maksymilian
Rudkowski, Krzysztof
Kucharska-Mazur, Jolanta
Andrusewicz, Wojciech
Misiak, Błażej
Szulc, Agata
Michalczyk, Anna
Michałowska, Sylwia
Sagan, Leszek
Samochowiec, Jerzy
author_facet Podwalski, Piotr
Tyburski, Ernest
Szczygieł, Krzysztof
Waszczuk, Katarzyna
Rek-Owodziń, Katarzyna
Mak, Monika
Plichta, Piotr
Bielecki, Maksymilian
Rudkowski, Krzysztof
Kucharska-Mazur, Jolanta
Andrusewicz, Wojciech
Misiak, Błażej
Szulc, Agata
Michalczyk, Anna
Michałowska, Sylwia
Sagan, Leszek
Samochowiec, Jerzy
author_sort Podwalski, Piotr
collection PubMed
description Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-deficit schizophrenia (NDS) patients. We also investigated the psychopathological dimensions of schizophrenia and their relationship to CC integrity. Fifteen DS patients, 40 NDS patients, and 30 healthy controls (HC) underwent psychiatric evaluation and neuroimaging. We divided the CC into five regions and assessed their fractional anisotropy (FA) and mean diffusivity (MD). Psychopathology was assessed with the Positive and Negative Syndrome Scale. DS patients had lower FA than NDS patients and HC, and higher MD in Region 5 of the CC than did HC. NDS patients had higher MD in Region 4 of the CC. The patient groups differed in terms of negative symptoms. After differentiating clinical groups and HC, no significant correlations were observed between DTI measures and psychopathological symptoms. Our results suggest that DS and NDS are characterized by minor impairments of the posterior CC. We confirmed that DS patients have greater negative psychopathology than NDS patients. Our results are preliminary, and further studies are needed.
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spelling pubmed-81966212021-06-13 White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients Podwalski, Piotr Tyburski, Ernest Szczygieł, Krzysztof Waszczuk, Katarzyna Rek-Owodziń, Katarzyna Mak, Monika Plichta, Piotr Bielecki, Maksymilian Rudkowski, Krzysztof Kucharska-Mazur, Jolanta Andrusewicz, Wojciech Misiak, Błażej Szulc, Agata Michalczyk, Anna Michałowska, Sylwia Sagan, Leszek Samochowiec, Jerzy J Clin Med Article Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-deficit schizophrenia (NDS) patients. We also investigated the psychopathological dimensions of schizophrenia and their relationship to CC integrity. Fifteen DS patients, 40 NDS patients, and 30 healthy controls (HC) underwent psychiatric evaluation and neuroimaging. We divided the CC into five regions and assessed their fractional anisotropy (FA) and mean diffusivity (MD). Psychopathology was assessed with the Positive and Negative Syndrome Scale. DS patients had lower FA than NDS patients and HC, and higher MD in Region 5 of the CC than did HC. NDS patients had higher MD in Region 4 of the CC. The patient groups differed in terms of negative symptoms. After differentiating clinical groups and HC, no significant correlations were observed between DTI measures and psychopathological symptoms. Our results suggest that DS and NDS are characterized by minor impairments of the posterior CC. We confirmed that DS patients have greater negative psychopathology than NDS patients. Our results are preliminary, and further studies are needed. MDPI 2021-05-21 /pmc/articles/PMC8196621/ /pubmed/34063845 http://dx.doi.org/10.3390/jcm10112225 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Podwalski, Piotr
Tyburski, Ernest
Szczygieł, Krzysztof
Waszczuk, Katarzyna
Rek-Owodziń, Katarzyna
Mak, Monika
Plichta, Piotr
Bielecki, Maksymilian
Rudkowski, Krzysztof
Kucharska-Mazur, Jolanta
Andrusewicz, Wojciech
Misiak, Błażej
Szulc, Agata
Michalczyk, Anna
Michałowska, Sylwia
Sagan, Leszek
Samochowiec, Jerzy
White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
title White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
title_full White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
title_fullStr White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
title_full_unstemmed White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
title_short White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
title_sort white matter integrity of the corpus callosum and psychopathological dimensions in deficit and non-deficit schizophrenia patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196621/
https://www.ncbi.nlm.nih.gov/pubmed/34063845
http://dx.doi.org/10.3390/jcm10112225
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