Cargando…
White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196621/ https://www.ncbi.nlm.nih.gov/pubmed/34063845 http://dx.doi.org/10.3390/jcm10112225 |
_version_ | 1783706728511045632 |
---|---|
author | Podwalski, Piotr Tyburski, Ernest Szczygieł, Krzysztof Waszczuk, Katarzyna Rek-Owodziń, Katarzyna Mak, Monika Plichta, Piotr Bielecki, Maksymilian Rudkowski, Krzysztof Kucharska-Mazur, Jolanta Andrusewicz, Wojciech Misiak, Błażej Szulc, Agata Michalczyk, Anna Michałowska, Sylwia Sagan, Leszek Samochowiec, Jerzy |
author_facet | Podwalski, Piotr Tyburski, Ernest Szczygieł, Krzysztof Waszczuk, Katarzyna Rek-Owodziń, Katarzyna Mak, Monika Plichta, Piotr Bielecki, Maksymilian Rudkowski, Krzysztof Kucharska-Mazur, Jolanta Andrusewicz, Wojciech Misiak, Błażej Szulc, Agata Michalczyk, Anna Michałowska, Sylwia Sagan, Leszek Samochowiec, Jerzy |
author_sort | Podwalski, Piotr |
collection | PubMed |
description | Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-deficit schizophrenia (NDS) patients. We also investigated the psychopathological dimensions of schizophrenia and their relationship to CC integrity. Fifteen DS patients, 40 NDS patients, and 30 healthy controls (HC) underwent psychiatric evaluation and neuroimaging. We divided the CC into five regions and assessed their fractional anisotropy (FA) and mean diffusivity (MD). Psychopathology was assessed with the Positive and Negative Syndrome Scale. DS patients had lower FA than NDS patients and HC, and higher MD in Region 5 of the CC than did HC. NDS patients had higher MD in Region 4 of the CC. The patient groups differed in terms of negative symptoms. After differentiating clinical groups and HC, no significant correlations were observed between DTI measures and psychopathological symptoms. Our results suggest that DS and NDS are characterized by minor impairments of the posterior CC. We confirmed that DS patients have greater negative psychopathology than NDS patients. Our results are preliminary, and further studies are needed. |
format | Online Article Text |
id | pubmed-8196621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81966212021-06-13 White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients Podwalski, Piotr Tyburski, Ernest Szczygieł, Krzysztof Waszczuk, Katarzyna Rek-Owodziń, Katarzyna Mak, Monika Plichta, Piotr Bielecki, Maksymilian Rudkowski, Krzysztof Kucharska-Mazur, Jolanta Andrusewicz, Wojciech Misiak, Błażej Szulc, Agata Michalczyk, Anna Michałowska, Sylwia Sagan, Leszek Samochowiec, Jerzy J Clin Med Article Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-deficit schizophrenia (NDS) patients. We also investigated the psychopathological dimensions of schizophrenia and their relationship to CC integrity. Fifteen DS patients, 40 NDS patients, and 30 healthy controls (HC) underwent psychiatric evaluation and neuroimaging. We divided the CC into five regions and assessed their fractional anisotropy (FA) and mean diffusivity (MD). Psychopathology was assessed with the Positive and Negative Syndrome Scale. DS patients had lower FA than NDS patients and HC, and higher MD in Region 5 of the CC than did HC. NDS patients had higher MD in Region 4 of the CC. The patient groups differed in terms of negative symptoms. After differentiating clinical groups and HC, no significant correlations were observed between DTI measures and psychopathological symptoms. Our results suggest that DS and NDS are characterized by minor impairments of the posterior CC. We confirmed that DS patients have greater negative psychopathology than NDS patients. Our results are preliminary, and further studies are needed. MDPI 2021-05-21 /pmc/articles/PMC8196621/ /pubmed/34063845 http://dx.doi.org/10.3390/jcm10112225 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Podwalski, Piotr Tyburski, Ernest Szczygieł, Krzysztof Waszczuk, Katarzyna Rek-Owodziń, Katarzyna Mak, Monika Plichta, Piotr Bielecki, Maksymilian Rudkowski, Krzysztof Kucharska-Mazur, Jolanta Andrusewicz, Wojciech Misiak, Błażej Szulc, Agata Michalczyk, Anna Michałowska, Sylwia Sagan, Leszek Samochowiec, Jerzy White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients |
title | White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients |
title_full | White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients |
title_fullStr | White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients |
title_full_unstemmed | White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients |
title_short | White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients |
title_sort | white matter integrity of the corpus callosum and psychopathological dimensions in deficit and non-deficit schizophrenia patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196621/ https://www.ncbi.nlm.nih.gov/pubmed/34063845 http://dx.doi.org/10.3390/jcm10112225 |
work_keys_str_mv | AT podwalskipiotr whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT tyburskiernest whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT szczygiełkrzysztof whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT waszczukkatarzyna whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT rekowodzinkatarzyna whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT makmonika whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT plichtapiotr whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT bieleckimaksymilian whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT rudkowskikrzysztof whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT kucharskamazurjolanta whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT andrusewiczwojciech whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT misiakbłazej whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT szulcagata whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT michalczykanna whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT michałowskasylwia whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT saganleszek whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients AT samochowiecjerzy whitematterintegrityofthecorpuscallosumandpsychopathologicaldimensionsindeficitandnondeficitschizophreniapatients |