Inflammation-Induced Tumorigenesis and Metastasis

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how infla...

Descripción completa

Detalles Bibliográficos
Autores principales: Hibino, Sana, Kawazoe, Tetsuro, Kasahara, Hidenori, Itoh, Shinji, Ishimoto, Takatsugu, Sakata-Yanagimoto, Mamiko, Taniguchi, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196678/
https://www.ncbi.nlm.nih.gov/pubmed/34063828
http://dx.doi.org/10.3390/ijms22115421
_version_ 1783706741523873792
author Hibino, Sana
Kawazoe, Tetsuro
Kasahara, Hidenori
Itoh, Shinji
Ishimoto, Takatsugu
Sakata-Yanagimoto, Mamiko
Taniguchi, Koji
author_facet Hibino, Sana
Kawazoe, Tetsuro
Kasahara, Hidenori
Itoh, Shinji
Ishimoto, Takatsugu
Sakata-Yanagimoto, Mamiko
Taniguchi, Koji
author_sort Hibino, Sana
collection PubMed
description Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.
format Online
Article
Text
id pubmed-8196678
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81966782021-06-13 Inflammation-Induced Tumorigenesis and Metastasis Hibino, Sana Kawazoe, Tetsuro Kasahara, Hidenori Itoh, Shinji Ishimoto, Takatsugu Sakata-Yanagimoto, Mamiko Taniguchi, Koji Int J Mol Sci Review Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies. MDPI 2021-05-21 /pmc/articles/PMC8196678/ /pubmed/34063828 http://dx.doi.org/10.3390/ijms22115421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hibino, Sana
Kawazoe, Tetsuro
Kasahara, Hidenori
Itoh, Shinji
Ishimoto, Takatsugu
Sakata-Yanagimoto, Mamiko
Taniguchi, Koji
Inflammation-Induced Tumorigenesis and Metastasis
title Inflammation-Induced Tumorigenesis and Metastasis
title_full Inflammation-Induced Tumorigenesis and Metastasis
title_fullStr Inflammation-Induced Tumorigenesis and Metastasis
title_full_unstemmed Inflammation-Induced Tumorigenesis and Metastasis
title_short Inflammation-Induced Tumorigenesis and Metastasis
title_sort inflammation-induced tumorigenesis and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196678/
https://www.ncbi.nlm.nih.gov/pubmed/34063828
http://dx.doi.org/10.3390/ijms22115421
work_keys_str_mv AT hibinosana inflammationinducedtumorigenesisandmetastasis
AT kawazoetetsuro inflammationinducedtumorigenesisandmetastasis
AT kasaharahidenori inflammationinducedtumorigenesisandmetastasis
AT itohshinji inflammationinducedtumorigenesisandmetastasis
AT ishimototakatsugu inflammationinducedtumorigenesisandmetastasis
AT sakatayanagimotomamiko inflammationinducedtumorigenesisandmetastasis
AT taniguchikoji inflammationinducedtumorigenesisandmetastasis

Ejemplares similares