Cargando…

Triple-Knockout, Synuclein-Free Mice Display Compromised Lipid Pattern

Recent studies have implicated synucleins in several reactions during the biosynthesis of lipids and fatty acids in addition to their recognised role in membrane lipid binding and synaptic functions. These are among aspects of decreased synuclein functions that are still poorly acknowledged especial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guschina, Irina A., Ninkina, Natalia, Roman, Andrei, Pokrovskiy, Mikhail V., Buchman, Vladimir L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196748/ https://www.ncbi.nlm.nih.gov/pubmed/34064018 http://dx.doi.org/10.3390/molecules26113078

Ejemplares similares

Lipid Classes and Fatty Acid Patterns are Altered in the Brain of γ-Synuclein Null Mutant Mice
por: Guschina, Irina, et al.
Publicado: (2010)

γ-synuclein is a novel player in the control of body lipid metabolism
por: Millership, Steven, et al.
Publicado: (2013)

Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?
por: Buchman, Vladimir L., et al.
Publicado: (2008)

Compromised paraspeckle formation as a pathogenic factor in FUSopathies
por: Shelkovnikova, Tatyana A., et al.
Publicado: (2014)

Synuclein Deficiency Results in Age-Related Respiratory and Cardiovascular Dysfunctions in Mice
por: Hosford, Patrick S., et al.
Publicado: (2020)

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses
por: Ninkina, Natalia, et al.
Publicado: (2012)

Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism
por: Connor-Robson, Natalie, et al.
Publicado: (2016)

Gamma-synuclein pathology in amyotrophic lateral sclerosis
por: Peters, Owen M, et al.
Publicado: (2015)

Loss of the Synuclein Family Members Differentially Affects Baseline- and Apomorphine-Associated EEG Determinants in Single-, Double- and Triple-Knockout Mice
por: Vorobyov, Vasily, et al.
Publicado: (2022)

Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice()
por: Al-Wandi, Abdelmojib, et al.
Publicado: (2010)

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice
por: Ninkina, Natalia, et al.
Publicado: (2020)

A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression
por: Ninkina, Natalia, et al.
Publicado: (2015)

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis
por: Peters, Owen M., et al.
Publicado: (2012)

β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
por: Ninkina, Natalia, et al.
Publicado: (2021)

Dimebon Slows Progression of Proteinopathy in γ-Synuclein Transgenic Mice
por: Bachurin, Sergey O., et al.
Publicado: (2011)

Editorial of the Special Issue: Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease
por: Ninkina, Natalia, et al.
Publicado: (2023)

Dimebon Does Not Ameliorate Pathological Changes Caused by Expression of Truncated (1–120) Human Alpha-Synuclein in Dopaminergic Neurons of Transgenic Mice
por: Shelkovnikova, Tatyana A., et al.
Publicado: (2011)

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive “low footprint” genetic knockout of alpha-synuclein
por: Goloborshcheva, Valeria V., et al.
Publicado: (2020)

Generation of mouse lines with conditionally or constitutively inactivated Snca gene and Rosa26-stop-lacZ reporter located in cis on the mouse chromosome 6
por: Roman, Andrei Yu., et al.
Publicado: (2016)

γ-Synuclein Is an Adipocyte-Neuron Gene Coordinately Expressed with Leptin and Increased in Human Obesity
por: Oort, Pieter J., et al.
Publicado: (2008)

α-Synuclein leaves autophagy feeling compromised
por: Short, Ben
Publicado: (2010)

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms
por: Shelkovnikova, Tatyana A., et al.
Publicado: (2014)

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein
por: Ninkina, Natalia, et al.
Publicado: (2009)

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages
por: Haenseler, Walther, et al.
Publicado: (2017)

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2011)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2012)

Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol
por: Kokhan, Viktor S., et al.
Publicado: (2022)

Differential involvement of the gamma-synuclein in cognitive abilities on the model of knockout mice
por: Kokhan, Viktor S, et al.
Publicado: (2013)

Analysis of α-Synuclein Pathology in PINK1 Knockout Rat Brains
por: Creed, Rose B., et al.
Publicado: (2019)

Quantification of Lipids: Model, Reality, and Compromise
por: Khoury, Spiro, et al.
Publicado: (2018)

Adiponectin Knockout Mice Display Cognitive and Synaptic Deficits
por: Bloemer, Jenna, et al.
Publicado: (2019)

Stem cells in human breast milk
por: Ninkina, Natalia, et al.
Publicado: (2019)

Lipid peroxidation is essential for α‐synuclein‐induced cell death
por: Angelova, Plamena R., et al.
Publicado: (2015)

Light-Induced Changes in Fatty Acid Profiles of Specific Lipid Classes in Several Freshwater Phytoplankton Species
por: Wacker, Alexander, et al.
Publicado: (2016)

Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation
por: Buchman, Vladimir L, et al.
Publicado: (2013)

Alpha-Synuclein and Lipids: The Elephant in the Room?
por: Sarchione, Alessia, et al.
Publicado: (2021)

Hunk/Mak-v is a negative regulator of intestinal cell proliferation
por: Reed, Karen R, et al.
Publicado: (2015)

Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways
por: Parks, Sophia C., et al.
Publicado: (2021)

Stem cell therapy and FUS[1‐359]‐transgenic mice: A recent study highlighting a promising ALS model and a promising therapy
por: Ninkina, Natalia
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_onkukclb7n3gesmmg7kd2v7coa